Recent Submissions

  • The Spatial and Temporal Influence of Cloud Cover on Satellite-Based Emergency Mapping of Earthquake Disasters 

    Rosser N; Walters RJ; Robinson, Tom (Springer Science and Business Media LLC, 2019)
    The ability to rapidly access optical satellite imagery is now an intrinsic component of managing the disaster response that follows a major earthquake. These images provide synoptic data on the impacts, extent, and intensity ...
  • Food for people in place: reimagining resilient food systems for economic recovery 

    Diprose G; Sharp E; Graham R; Lee L; Richardson S; Watkins A; Martin-Neuninger R; Dombroski, Kelly; Scobie, Matthew (MDPI AG, 2020)
    The COVID-19 pandemic and associated response have brought food security into sharp focus for many New Zealanders. The requirement to “shelter in place” for eight weeks nationwide, with only “essential services” operating, ...
  • KMT-2017-BLG-2820 and the nature of the free-floating planet population 

    Ryu YH; Mróz P; Gould A; Hwang KH; Kim HW; Yee JC; Chung SJ; Jung YK; Shin IG; Shvartzvald Y; Zang W; Cha SM; Kim DJ; Kim SL; Lee CU; Lee DJ; Lee Y; Park BG; Han C; Pogge RW; Udalski A; Poleski R; Skowron J; Szymański MK; Soszyński I; Pietrukowicz P; Kozłowski S; Ulaczyk K; Rybicki KA; Iwanek P; Albrow, Michael (American Astronomical Society, 2021)
    We report a new free-floating planet (FFP) candidate, KMT-2017-BLG-2820, with Einstein radius θ ; 6 μas, lens-source relative proper motion μ ; 8 mas yr , and Einstein timescale t = 6.5 hr. It is the third FFP candidate ...
  • KMT-2019-BLG-0797: Binary-lensing event occurring on a binary stellar system 

    Han C; Lee CU; Ryu YH; Kim D; Chung SJ; Gould A; Hwang KH; Jung YK; Kim HW; Shin IG; Shvartzvald Y; Yee JC; Zang W; Cha SM; Kim DJ; Kim SL; Lee DJ; Lee Y; Park BG; Pogge RW; Albrow, Michael (EDP Sciences, 2021)
    Aims. We analyze the microlensing event KMT-2019-BLG-0797. The light curve of the event exhibits two anomalous features from a single-lens single-source model, and we aim to reveal the nature of the anomaly. Methods. It ...
  • How neurons exploit fractal geometry to optimize their network connectivity 

    Smith JH; Rowland C; Harland B; Moslehi S; Montgomery RD; Schobert K; Watterson WJ; Taylor RP; Dalrymple-Alford, John (Springer Science and Business Media LLC, 2021)
    We investigate the degree to which neurons are fractal, the origin of this fractality, and its impact on functionality. By analyzing three-dimensional images of rat neurons, we show the way their dendrites fork and weave ...
  • Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders 

    Nabais MF; Laws SM; Lin T; Vallerga CL; Armstrong NJ; Blair IP; Kwok JB; Mather KA; Mellick GD; Sachdev PS; Wallace L; Henders AK; Zwamborn RAJ; Hop PJ; Lunnon K; Pishva E; Roubroeks JAY; Soininen H; Tsolaki M; Mecocci P; Lovestone S; Kłoszewska I; Vellas B; Furlong S; Garton FC; Henderson RD; Mathers S; McCombe PA; Needham M; Ngo ST; Nicholson G; Pamphlett R; Rowe DB; Steyn FJ; Williams KL; Anderson TJ; Bentley SR; Fowder J; Gratten J; Halliday G; Hickie IB; Kennedy M; Lewis SJG; Montgomery GW; Pearson J; Pitcher TL; Silburn P; Zhang F; Visscher PM; Yang J; Stevenson AJ; Hillary RF; Marioni RE; Harris SE; Deary IJ; Jones AR; Shatunov A; Iacoangeli A; van Rheenen W; van den Berg LH; Shaw PJ; Shaw CE; Morrison KE; Al-Chalabi A; Veldink JH; Hannon E; Mill J; Wray NR; McRae AF; Dalrymple-Alford, John (Springer Science and Business Media LLC, 2021)
    Background: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) ...
  • Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis 

    Castellazzi G; Debernard L; Melzer TR; D'Angelo E; Miller DH; Wheeler-Kingshott CAMG; Mason DF; Dalrymple-Alford, John (Frontiers Media SA, 2018)
    © 2018 Castellazzi, Debernard, Melzer, Dalrymple-Alford, D'Angelo, Miller, Gandini Wheeler-Kingshott and Mason. Resting state functional MRI (rs-fMRI) has provided important insights into functional reorganization in ...
  • Positive association of ascorbate and inverse association of urate with cognitive function in people with Parkinson’s disease 

    Spencer ES; Pitcher T; Veron G; Hannam T; Macaskill M; Anderson T; Carr AC; Dalrymple-Alford, John (MDPI AG, 2020)
    Oxidative stress is thought to contribute to the aetiology of neurological disorders such as Parkinson’s disease. Ascorbate (vitamin C) is a potent antioxidant and is associated with neurological and cognitive function. ...
  • Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease 

    Vallerga CL; Zhang F; Fowdar J; McRae AF; Qi T; Nabais MF; Zhang Q; Kassam I; Henders AK; Wallace L; Montgomery G; Chuang YH; Horvath S; Ritz B; Halliday G; Hickie I; Kwok JB; Pearson J; Pitcher T; Kennedy M; Bentley SR; Silburn PA; Yang J; Wray NR; Lewis SJG; Anderson T; Mellick GD; Visscher PM; Gratten J; Dalrymple-Alford, John (Springer Science and Business Media LLC, 2020)
    An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present results from a ...
  • Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults 

    Hofer E; Roshchupkin GV; Adams HHH; Knol MJ; Lin H; Li S; Zare H; Ahmad S; Armstrong NJ; Satizabal CL; Bernard M; Bis JC; Gillespie NA; Luciano M; Mishra A; Scholz M; Teumer A; Xia R; Jian X; Mosley TH; Saba Y; Pirpamer L; Seiler S; Becker JT; Carmichael O; Rotter JI; Psaty BM; Lopez OL; Amin N; van der Lee SJ; Yang Q; Himali JJ; Maillard P; Beiser AS; Decarli C; Karama S; Lewis L; Harris M; Bastin ME; Deary IJ; Witte AV; Beyer F; Loeffler M; Mather KA; Schofield PR; Thalamuthu A; Kwok JB; Wright MJ; Ames D; Trollor J; Jiang J; Brodaty H; Wen W; Vernooij MW; Hofman A; Uitterlinden AG; Niessen WJ; Wittfeld K; Bülow R; Völker U; Pausova Z; Pike GB; Maingault S; Crivello F; Tzourio C; Amouyel P; Mazoyer B; Neale MC; Franz CE; Lyons MJ; Panizzon MS; Andreassen OA; Dale AM; Logue M; Grasby KL; Jahanshad N; Painter JN; Colodro-Conde L; Bralten J; Hibar DP; Lind PA; Pizzagalli F; Stein JL; Thompson PM; Medland SE; Sachdev PS; Kremen WS; Wardlaw JM; Villringer A; van Duijn CM; Grabe HJ; Longstreth WT; Fornage M; Paus T; Debette S; Ikram MA; Schmidt H; Schmidt R; Seshadri S; Ching CRK (Springer Science and Business Media LLC, 2020)
    Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ...
  • Pyroluria: Fact or Fiction? 

    Warren B; Sarris J; Mulder RT; Rucklidge, Julia (Mary Ann Liebert Inc, 2021)
    Objective: The term "Mauve factor" (pyrroluria) dates back to 1958 when Dr. Abram Hoffer defined the condition as elevated levels of pyrroles in the urine, currently called hydroxyhemepyrrolin-2-one (HPL). It was suggested ...
  • Beta amyloid deposition is not associated with cognitive impairment in Parkinson's disease 

    Melzer TR; Stark MR; Keenan RJ; Myall DJ; MacAskill MR; Pitcher TL; Livingston L; Grenfell S; Horne KL; Young BN; Pascoe MJ; Almuqbel MM; Wang J; Miller DH; Anderson TJ; Marsh, Steven; Dalrymple-Alford, John (Frontiers Media SA, 2019)
    The extent to which Alzheimer neuropathology, particularly the accumulation of misfolded beta-amyloid, contributes to cognitive decline and dementia in Parkinson's disease (PD) is unresolved. Here, we used Florbetaben PET ...
  • Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies 

    Nalls MA; Blauwendraat C; Vallerga CL; Heilbron K; Bandres-Ciga S; Chang D; Tan M; Kia DA; Noyce AJ; Xue A; Bras J; Young E; von Coelln R; Simón-Sánchez J; Schulte C; Sharma M; Krohn L; Pihlstrøm L; Siitonen A; Iwaki H; Leonard H; Faghri F; Gibbs JR; Hernandez DG; Scholz SW; Botia JA; Martinez M; Corvol JC; Lesage S; Jankovic J; Shulman LM; Sutherland M; Tienari P; Majamaa K; Toft M; Andreassen OA; Bangale T; Brice A; Yang J; Gan-Or Z; Gasser T; Heutink P; Shulman JM; Wood NW; Hinds DA; Hardy JA; Morris HR; Gratten J; Visscher PM; Graham RR; Singleton AB; Adarmes-Gómez AD; Aguilar M; Aitkulova A; Akhmetzhanov V; Alcalay RN; Alvarez I; Alvarez V; Barrero FJ; Bergareche Yarza JA; Bernal-Bernal I; Billingsley K; Blazquez M; Bonilla-Toribio M; Boungiorno MT; Brockmann K; Bubb V; Buiza-Rueda D; Cámara A; Carrillo F; Carrión-Claro M; Cerdan D; Chelban V; Clarimón J; Clarke C; Compta Y; Cookson MR; Craig DW; Danjou F; Diez-Fairen M; Dols-Icardo O; Duarte J; Duran R; Escamilla-Sevilla F; Escott-Price V; Ezquerra M; Feliz C; Fernández M; Fernández-Santiago R; Finkbeiner S; Foltynie T; Garcia C; García-Ruiz P; Gomez Heredia MJ; Gómez-Garre P; González MM; Gonzalez-Aramburu I; Guelfi S; Guerreiro R (Elsevier BV, 2019)
    Background: Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to ...
  • Supplementation of blackcurrant anthocyanins increased cyclic glycine-proline in the cerebrospinal fluid of parkinson patients: Potential treatment to improve insulin-like growth factor-1 function 

    Fan D; Alamri Y; Liu K; Macaskill M; Harris P; Brimble M; Prickett T; Menzies O; Laurenson A; Anderson T; Guan J; Dalrymple-Alford, John (MDPI AG, 2018)
    Background: Insulin-like growth factor-1 (IGF-1) function is impaired in Parkinson disease. Cyclic glycine-proline (cGP), a metabolite of IGF-1, is neuroprotective through improving IGF-1 function. Parkinson disease patients ...
  • Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability 

    Botía J; Nalls MA; Noyce AJ; Nicolas A; Cookson MR; Bandres-Ciga S; Gibbs JR; Hernandez DG; Singleton AB; Reed X; Leonard H; Blauwendraat C; Faghri F; Bras J; Guerreiro R; Tucci A; Kia DA; Houlden H; Plun-Favreau H; Mok KY; Wood NW; Lovering R; R’Bibo L; Rizig M; Chelban V; Trabzuni D; Tan M; Morris HR; Middlehurst B; Quinn J; Billingsley K; Holmans P; Kinghorn KJ; Lewis P; Escott-Price V; Williams N; Foltynie T; Brice A; Danjou F; Lesage S; Corvol JC; Martinez M; Giri A; Schulte C; Brockmann K; Simón-Sánchez J; Heutink P; Gasser T; Rizzu P; Sharma M; Shulman JM; Robak L; Lubbe S; Mencacci NE; Finkbeiner S; Lungu C; Scholz SW; Gan-Or Z; Rouleau GA; Krohan L; van Hilten JJ; Marinus J; Adarmes-Gómez AD; Bernal-Bernal I; Bonilla-Toribio M; Buiza-Rueda D; Carrillo F; Carrión-Claro M; Mir P; Gómez-Garre P; Jesús S; Labrador-Espinosa MA; Macias D; Vargas-González L; Méndez-del-Barrio C; Periñán-Tocino T; Tejera-Parrado C; Diez-Fairen M; Aguilar M; Alvarez I; Boungiorno MT; Carcel M; Pastor P; Tartari JP; Alvarez V; González MM; Blazquez M; Garcia C; Suarez-Sanmartin E; Barrero FJ; Rezola EM; Yarza JAB; Pagola AG; de Munain Arregui AL; Ruiz-Martínez J; Cerdan D; Duarte J; Clarimón J; Dols-Icardo O; Reynolds, Regina (Springer Science and Business Media LLC, 2019)
    Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence ...
  • Changes of plasma cGP/IGF-1 molar ratio with age is associated with cognitive status of Parkinson disease 

    Fan D; MacAskill M; Anderson T; Guan J; Dalrymple-Alford, John; Pitcher, Toni (Wiley, 2020)
    Objective: Cognitive impairment is a common feature of Parkinson disease (PD), for which age is a major contributing factor. Insulin-like growth factor-1 (IGF-1) declines with age and contributes to age-related cognitive ...
  • Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats 

    Rapley SA; Prickett TCR; Espiner EA; Dalrymple-Alford, John (Frontiers Media SA, 2018)
    Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type ...
  • KMT-2018-BLG-1025Lb: Microlensing super-Earth planet orbiting a low-mass star 

    Han C; Udalski A; Lee CU; Chung SJ; Gould A; Hwang KH; Jung YK; Kim D; Kim HW; Ryu YH; Shin IG; Shvartzvald Y; Yee JC; Zang W; Cha SM; Kim DJ; Kim SL; Lee DJ; Lee Y; Park BG; Pogge RW; Kim CH; Kim WT; Mróz P; Szymański MK; Skowron J; Poleski R; Soszyński I; Pietrukowicz P; Kozłowski S; Ulaczyk K; Rybicki KA; Iwanek P; Wrona M; Albrow, Michael (EDP Sciences, 2021)
    Aims. We aim to find missing microlensing planets hidden in the unanalyzed lensing events of previous survey data. Methods. For this purpose, we conducted a systematic inspection of high-magnification microlensing events, ...
  • OGLE-2018-BLG-0567Lb and OGLE-2018-BLG-0962Lb: Two Microlensing Planets through Planetary-Caustic Channel 

    Jung YK; Han C; Udalski A; Gould A; Yee JC; Chung S-J; Hwang K-H; Ryu Y-H; Shin I-G; Shvartzvald Y; Zhu W; Zang W; Cha S-M; Kim D-J; Kim H-W; Kim S-L; Lee C-U; Lee D-J; Lee Y; Park B-G; Mróz RWPP; Szymański MK; Skowron J; Poleski R; Soszyński I; Pietrukowicz P; Kozłowski S; Ulaczyk K; Rybicki KA; Iwanek P; Wrona M; Albrow, Michael (American Astronomical Society, 2021)
    We present the analyses of two microlensing events, OGLE-2018-BLG-0567 and OGLE-2018-BLG-0962. In both events, the short-lasting anomalies were densely and continuously covered by two high-cadence surveys. The light-curve ...
  • OGLE-2018-BLG-1428Lb: a Jupiter-mass planet beyond the snow line of a dwarf star 

    Kim Y-H; Chung S-J; Udalski A; Gould A; Jung YK; Hwang K-H; Han C; Ryu Y-H; Shin I-G; Yee JC; Zang W; Cha S-M; Kim D-J; Kim H-W; Kim S-L; Lee C-U; Lee D-J; Lee Y; Park B-G; Pogge RW; Mróz P; Poleski R; Wrona M; Iwanek P; Szymański MK; Skowron J; Soszyński I; Kozłowski S; Pietrukowicz P; Ulaczyk K; Rybicki K; Albrow, Michael (Oxford University Press (OUP), 2021)
    We present the analysis of the microlensing event OGLE-2018-BLG-1428, which has a short-duration ($\sim 1$ day) caustic-crossing anomaly. The event was caused by a planetary lens system with planet/host mass ratio $q= ...

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