Pterins as diagnostic markers of mechanical and impact-induced trauma: A systematic review

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dc.contributor.authorLindsay A
dc.contributor.authorBaxter-Parker G
dc.contributor.authorGieseg, Steven
dc.date.accessioned2022-06-13T22:10:05Z
dc.date.available2022-06-13T22:10:05Z
dc.date.issued2019en
dc.date.updated2022-03-25T01:14:52Z
dc.description.abstractWe performed a systematic review of the literature to evaluate pterins as biomarkers of mechanical and impact-induced trauma. MEDLINE and Scopus were searched in March 2019. We included in vivo human studies that measured a pterin in response to mechanical or impact-induced trauma with no underlying prior disease or complication. We included 40 studies with a total of 3829 subjects. Seventy-seven percent of studies measured a significant increase in a pterin, primarily neopterin or total neopterin (neopterin + 7,8-dihydroneopterin). Fifty-one percent of studies measured an increase within 24 h or trauma, while 46% measured increases beyond 48 h. Pterins also showed promise as predictors of post-trauma complications such as sepsis, multi-organ failure and mortality. Exercise-induced trauma and traumatic brain injury caused an immediate increase in neopterin or total neopterin, while patients of multiple trauma had elevated pterin levels that remained above baseline for several days. Pterin concentration changes in response to surgery were variable with patients undergoing cardiac surgery having immediate and sustained pterin increases, while hysterectomy, liver resection or hysterectomy showed no change. This review provides systematic evidence that pterins, in particular neopterin and total neopterin, increase in response to multiple forms of mechanical or impact-induced trauma.en
dc.identifier.citationLindsay A, Baxter-Parker G, Gieseg SP (2019). Pterins as diagnostic markers of mechanical and impact-induced trauma: A systematic review. Journal of Clinical Medicine. 8(9). 1383-1383.en
dc.identifier.doihttp://doi.org/10.3390/jcm8091383
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/10092/103786
dc.languageeng
dc.language.isoenen
dc.publisherMDPI AGen
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subjectbiopterinen
dc.subjectexerciseen
dc.subjectneopterinen
dc.subjectsurgeryen
dc.subjecttetrahydrobiopterinen
dc.subjecttraumaen
dc.subjecttraumatic brain injuryen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3209 - Neurosciencesen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3205 - Medical biochemistry and metabolomicsen
dc.titlePterins as diagnostic markers of mechanical and impact-induced trauma: A systematic reviewen
dc.typeJournal Articleen
uc.collegeFaculty of Science
uc.departmentSchool of Biological Sciences
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