Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients

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dc.contributor.authorBaxter-Parker G
dc.contributor.authorRoffe L
dc.contributor.authorJefferies J
dc.contributor.authorRaajasekar S
dc.contributor.authorHooper G
dc.contributor.authorMoltchanova, Elena
dc.contributor.authorGieseg, Steven
dc.date.accessioned2022-05-11T22:54:22Z
dc.date.available2022-05-11T22:54:22Z
dc.date.issued2021en
dc.date.updated2022-03-25T01:13:47Z
dc.description.abstractKnee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint. Here, we compare the stress of the two surgeries by measuring urinary neopterin and total neopterin as biomarkers of oxidative stress and inflammation. Urinary neopterin and total neopterin (neopterin + 7,8-dihydroneopterin) levels were analysed in 28 knee and 22 hip arthroplasty patients pre- and post-operatively to determine oxidative stress and inflammation levels. Total neopterin was 31.1% higher with knee arthroplasty (p<0.05). Urinary neopterin was 32.8% higher in the knee arthroplasty group versus hips. The increase in neopterin and total neopterin following a post-surgical decrease in levels was significant in both groups. Levels of neopterin and total neopterin were varied between patients, but all increased following surgery and subsided by day 28. The increased levels of urinary neopterin and total neopterin from knee arthroplasty indicate that knee osteoarthritis and arthroplasty is a more significant trauma to the body than hip osteoarthritis and arthroplasty surgery. This is also shown by faster inflammatory resolution following hip arthroplasty.en
dc.identifier.citationBaxter-Parker G, Roffe L, Moltchanova E, Jefferies J, Raajasekar S, Hooper G, Gieseg SP (2021). Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. PLoS ONE. 16(8 August). e0256072-.en
dc.identifier.doihttp://doi.org/10.1371/journal.pone.0256072
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10092/103672
dc.languageeng
dc.language.isoenen
dc.publisherPublic Library of Science (PLoS)en
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subjectHip Jointen
dc.subjectKnee Jointen
dc.subjectHumansen
dc.subjectOsteoarthritis, Kneeen
dc.subjectOsteoarthritis, Hipen
dc.subjectInflammationen
dc.subjectNeopterinen
dc.subjectArthroplasty, Replacement, Hipen
dc.subjectArthroplasty, Replacement, Kneeen
dc.subjectCohort Studiesen
dc.subjectOxidative Stressen
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectStress, Physiologicalen
dc.subjectBiomarkersen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320216 - Orthopaedicsen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320223 - Rheumatology and arthritisen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320226 - Surgeryen
dc.titleUrinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patientsen
dc.typeJournal Articleen
uc.collegeFaculty of Science
uc.departmentMathematics and Statistics
uc.departmentSchool of Biological Sciences
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