Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies

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dc.contributor.authorPacilè S
dc.contributor.authorDullin C
dc.contributor.authorBaran P
dc.contributor.authorTonutti M
dc.contributor.authorPerske C
dc.contributor.authorFischer U
dc.contributor.authorAlbers J
dc.contributor.authorArfelli F
dc.contributor.authorDreossi D
dc.contributor.authorMaksimenko A
dc.contributor.authorMayo SC
dc.contributor.authorNesterets YI
dc.contributor.authorTaba ST
dc.contributor.authorLewis S
dc.contributor.authorBrennan PC
dc.contributor.authorGureyev TE
dc.contributor.authorTromba G
dc.contributor.authorWienbeck S
dc.contributor.authorPavlov, Konstantin
dc.date.accessioned2021-09-23T01:36:04Z
dc.date.available2021-09-23T01:36:04Z
dc.date.issued2019en
dc.date.updated2021-07-02T23:35:43Z
dc.description.abstractIn this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.en
dc.identifier.citationPacilè S, Dullin C, Baran P, Tonutti M, Perske C, Fischer U, Albers J, Arfelli F, Dreossi D, Pavlov K, Maksimenko A, Mayo SC, Nesterets YI, Taba ST, Lewis S, Brennan PC, Gureyev TE, Tromba G, Wienbeck S (2019). Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies. Scientific Reports. 9(1). 13762-.en
dc.identifier.doihttp://doi.org/10.1038/s41598-019-50075-6
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10092/102534
dc.languageeng
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subjectBreasten
dc.subjectHumansen
dc.subjectBreast Neoplasmsen
dc.subjectTomography, X-Ray Computeden
dc.subjectMastectomyen
dc.subjectFeasibility Studiesen
dc.subjectRadiation Dosageen
dc.subjectPhantoms, Imagingen
dc.subjectSynchrotronsen
dc.subjectFemaleen
dc.subjectCone-Beam Computed Tomographyen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineeringen
dc.subject.anzsrcFields of Research::51 - Physical sciences::5105 - Medical and biological physicsen
dc.titleFree propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomiesen
dc.typeJournal Articleen
uc.collegeFaculty of Science
uc.departmentSchool of Physical & Chemical Sciences
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