Model predictive glycaemic regulation in critical illness using insulin and nutrition input: a pilot study

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dc.contributor.authorWong, X-W.
dc.contributor.authorChase, Geoff
dc.contributor.authorShaw, Geoff
dc.contributor.authorHann, C.E.
dc.contributor.authorLotz, T.
dc.contributor.authorLin, J.
dc.contributor.authorSingh-Levett, I.
dc.contributor.authorHollingsworth, L.J.
dc.contributor.authorWong, O.S.W.
dc.contributor.authorAndreassen, S.
dc.date.accessioned2007-05-22T04:41:46Z
dc.date.available2007-05-22T04:41:46Z
dc.date.issued2006en
dc.description.abstractThis paper develops and presents a pilot study of a long-term controller for safe regulation of glycaemia under elevated insulin resistance and glucose intolerance in critically ill patients by modulating enteral nutrition inputs in addition to conventional basal-bolus intravenous insulin therapy. Clinical proof-of-concept pilot trials of the algorithm are performed which show the algorithm adaptability to time-varying intraas well as inter-patient variability in condition while requiring relatively infrequent glucose measurement. This research is a step towards randomized, comparative cohort studies of clinical outcomes using the developed protocol. Previous blood glucose control research includes controlled experiments in insulin infusion by Hovorka et al. [26], Chee et al. [27], and Chase et al. [18, 28]. Adaptive bolus-based control using insulin-alone by Chase et al. [18], is the basis of this work. The primary difference in this research is the improvement in control under elevated insulin resistance by modulation of nutritional support in addition to insulin inputen
dc.identifier.citationWong, X.W., Chase, J.G., Shaw, G.M., Hann, C.E., Lotz, T., Lin, J., Singh-Levett, I., Hollingsworth, L.J., Wong, O.S.W., Andreassen, S. (2006) Model predictive glycaemic regulation in critical illness using insulin and nutrition input: a pilot study. Medical Engineering and Physics, 28(7), pp. 665-681.en
dc.identifier.doihttps://doi.org/10.1016/j.medengphy.2005.10.015
dc.identifier.issn1350-4533
dc.identifier.urihttp://hdl.handle.net/10092/67
dc.language.isoen
dc.publisherUniversity of Canterbury. Chemical and Process Engineering.en
dc.publisherUniversity of Canterbury. Mechanical Engineering.en
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectCritical careen
dc.subjectHyperglycemiaen
dc.subjectRetrospective studiesen
dc.subjectICUen
dc.subjectBlood glucoseen
dc.subjectInsulinen
dc.subject.marsdenFields of Research::290000 Engineering and Technology::291500 Biomedical Engineering::291504 Biomechanical engineeringen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciencesen
dc.titleModel predictive glycaemic regulation in critical illness using insulin and nutrition input: a pilot studyen
dc.typeJournal Article
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