Simulation of left atrial function using a multi-scale model of the cardiovascular system

Type of content
Journal Article
Thesis discipline
Degree name
University of Canterbury. Mechanical Engineering
Journal Title
Journal ISSN
Volume Title
Pironet, A.
Dauby, P.C.
Paeme, S.
Kosta, S.
Chase, Geoff
Desaive, T.

The quick dynamic insulin sensitivity test (DISTq) can yield an insulin sensitivity result immediately after a 30-min clinical protocol. The test uses intravenous boluses of 10 g glucose and 1 U insulin at t = 1 and 11 min, respectively, and measures glucose levels in samples taken at t=0, 10, 20, and 30min. The low clinical cost of the protocol is enabled via robust model formulation and a series of population-derived relationships that estimate insulin pharmacokinetics as a function of insulin sensitivity (SI). Fifty individuals underwent the gold standard euglycaemic clamp (EIC) and DISTq within an eight-day period.SI values from the EIC and two DISTq variants (four-sample DISTq and two-sample DISTq30) were compared with correlation, Bland–Altman and receiver operator curve analyses. DISTq and DISTq30 correlated well with the EIC [R = 0.76 and 0.75, and receiver operator curve c-index = 0.84 and 0.85, respectively]. The median differences between EIC and DISTq/DISTq30 SI values were 13% and 22%, respectively. The DISTq estimation method predicted individual insulin responses without specific insulin assays with relative accuracy and thus high equivalence to EIC SI values was achieved. DISTq produced very inexpensive, relatively accurate immediate results, and can thus enable a number of applications that are impossible with established SI tests.

Pironet, A., Dauby, P.C., Paeme, S., Kosta, S., Chase, J.G., Desaive, T. (2013) Simulation of left atrial function using a multi-scale model of the cardiovascular system. PLOS ONE, 8(6), pp. e65146.
insulin sensitivity, parameter identification, structural model identifiability
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Fields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering
Field of Research::11 - Medical and Health Sciences::1102 - Cardiovascular Medicine and Haematology