Unified ethical principles and an animal research ‘Helsinki’ declaration as foundations for international collaboration

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dc.contributor.authorPetkov CI
dc.contributor.authorFlecknell P
dc.contributor.authorMurphy K
dc.contributor.authorBasso MA
dc.contributor.authorHartig R
dc.contributor.authorThompson-Iritani S
dc.contributor.authorMitchell, Anna S
dc.date.accessioned2023-01-12T20:47:10Z
dc.date.available2023-01-12T20:47:10Z
dc.date.issued2022en
dc.date.updated2022-12-11T22:52:36Z
dc.description.abstractEthical frameworks are the foundation for any research with humans or nonhuman animals. Human research is guided by overarching international ethical principles, such as those defined in the Helsinki Declaration by the World Medical Association. However, for nonhuman animal research, because there are several sets of ethical principles and national frameworks, it is commonly thought that there is substantial variability in animal research approaches internationally and a lack of an animal research ‘Helsinki Declaration’, or the basis for one. We first overview several prominent sets of ethical principles, including the 3Rs, 3Ss, 3Vs, 4Fs and 6Ps. Then using the 3Rs principles, originally proposed by Russell & Burch, we critically assess them, asking if they can be Replaced, Reduced or Refined. We find that the 3Rs principles have survived several replacement challenges, and the different sets of principles (3Ss, 3Vs, 4Fs and 6Ps) are complementary, a natural refinement of the 3Rs and are ripe for integration into a unified set of principles, as proposed here. We also overview international frameworks and documents, many of which incorporate the 3Rs, including the Basel Declaration on animal research. Finally, we propose that the available animal research guidance documents across countries can be consolidated, to provide a similar structure as seen in the Helsinki Declaration, potentially as part of an amended Basel Declaration on animal research. In summary, we observe substantially greater agreement on and the possibility for unification of the sets of ethical principles and documents that can guide animal research internationally.en
dc.identifier.citationPetkov CI, Flecknell P, Murphy K, Basso MA, Mitchell AS, Hartig R, Thompson-Iritani S (2022). Unified ethical principles and an animal research ‘Helsinki’ declaration as foundations for international collaboration. Current Research in Neurobiology. 3. 100060-100060.en
dc.identifier.doihttp://doi.org/10.1016/j.crneur.2022.100060
dc.identifier.issn2665-945X
dc.identifier.urihttps://hdl.handle.net/10092/104980
dc.languageen
dc.language.isoenen
dc.publisherElsevier BVen
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subject3Rsen
dc.subject3Ssen
dc.subject3Vsen
dc.subject4Fsen
dc.subject6Psen
dc.subjectethicsen
dc.subjectbioethicsen
dc.subjectregulationen
dc.subjectmoralityen
dc.subjectAAALACen
dc.subjectharm-benefit-analysisen
dc.subject.anzsrcFields of Research::50 - Philosophy and religious studies::5001 - Applied ethics::500101 - Bioethicsen
dc.titleUnified ethical principles and an animal research ‘Helsinki’ declaration as foundations for international collaborationen
dc.typeJournal Articleen
uc.collegeFaculty of Science
uc.departmentSchool of Psychology, Speech and Hearing
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