Supplementation of blackcurrant anthocyanins increased cyclic glycine-proline in the cerebrospinal fluid of parkinson patients: Potential treatment to improve insulin-like growth factor-1 function

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dc.contributor.authorFan D
dc.contributor.authorAlamri Y
dc.contributor.authorLiu K
dc.contributor.authorMacaskill M
dc.contributor.authorHarris P
dc.contributor.authorBrimble M
dc.contributor.authorPrickett T
dc.contributor.authorMenzies O
dc.contributor.authorLaurenson A
dc.contributor.authorAnderson T
dc.contributor.authorGuan J
dc.contributor.authorDalrymple-Alford, John
dc.date.accessioned2021-07-05T01:05:51Z
dc.date.available2021-07-05T01:05:51Z
dc.date.issued2018en
dc.date.updated2021-06-29T03:25:56Z
dc.description.abstractBackground: Insulin-like growth factor-1 (IGF-1) function is impaired in Parkinson disease. Cyclic glycine-proline (cGP), a metabolite of IGF-1, is neuroprotective through improving IGF-1 function. Parkinson disease patients score lower on Hospital-associated Anxiety and Depression Scale after supplementing blackcurrant anthocyanins (BCA), which may be associated with IGF-1 function. We evaluated the changes of cGP and IGF-1 before and after the supplementation. Methods: Plasma and cerebrospinal fluid (CSF) were collected from 11 male patients before and after 28 day supplementation of BCA. The concentrations of IGF-1, IGF binding protein (IGFBP)-3, and cGP were measured using ELISA and HPLC-MS assays. The presence of cGP in the BCA was evaluated. Results: cGP presented in the BCA. BCA supplementation increased the concentration of cGP (p < 0.01), but not IGF-1 and IGFBP-3 in the CSF. CSF concentration of cGP was correlated with plasma concentration of cGP (R = 0.68, p = 0.01) and cGP/IGF-1 molar ratio (R = 0.66, p = 0.01). The CSF/plasma ratio was high in cGP and low in IGF-1 and IGFBP-3. Conclusion: cGP is a natural nutrient to the BCA. The increased CSF cGP in Parkinson disease patients may result from the central uptake of plasma cGP. Given neurotrophic function, oral availability, and effective central uptake of cGP, the BCA has the potential to be developed to treat neurological conditions with IGF-1 deficiency.en
dc.identifier.citationFan D, Alamri Y, Liu K, Macaskill M, Harris P, Brimble M, Dalrymple-Alford J, Prickett T, Menzies O, Laurenson A, Anderson T, Guan J (2018). Supplementation of blackcurrant anthocyanins increased cyclic glycine-proline in the cerebrospinal fluid of parkinson patients: Potential treatment to improve insulin-like growth factor-1 function. Nutrients. 10(6). 714-714.en
dc.identifier.doihttp://doi.org/10.3390/nu10060714
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/10092/102171
dc.languageeng
dc.language.isoen
dc.publisherMDPI AGen
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subjectHumansen
dc.subjectRibesen
dc.subjectFruiten
dc.subjectParkinson Diseaseen
dc.subjectAnthocyaninsen
dc.subjectPeptides, Cyclicen
dc.subjectInsulin-Like Growth Factor Ien
dc.subjectInsulin-Like Growth Factor Binding Protein 3en
dc.subjectAntiparkinson Agentsen
dc.subjectTreatment Outcomeen
dc.subjectTime Factorsen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectNew Zealanden
dc.subjectMaleen
dc.subjectBiomarkersen
dc.subjectcyclic Glycine-Proline (cGP)en
dc.subjectbioavailability of insulin-like growth factor-1 (IGF-1)en
dc.subjectblackcurrant anthocyaninsen
dc.subjectautocrine regulationen
dc.subjectcerebrospinal fluiden
dc.subjectcentral uptakeen
dc.subject.anzsrc0908 Food Sciencesen
dc.subject.anzsrc1111 Nutrition and Dieteticsen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3209 - Neurosciences::320905 - Neurology and neuromuscular diseasesen
dc.subject.anzsrcFields of Research::52 - Psychology::5202 - Biological psychology::520203 - Cognitive neuroscienceen
dc.subject.anzsrcFields of Research::52 - Psychology::5202 - Biological psychology::520205 - Psychopharmacologyen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3210 - Nutrition and dietetics::321002 - Food properties (incl. characteristics and health benefits)en
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3210 - Nutrition and dietetics::321001 - Clinical nutritionen
dc.titleSupplementation of blackcurrant anthocyanins increased cyclic glycine-proline in the cerebrospinal fluid of parkinson patients: Potential treatment to improve insulin-like growth factor-1 functionen
dc.typeJournal Articleen
uc.collegeFaculty of Science
uc.departmentSchool of Psychology, Speech and Hearing
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