The effect of delta-9 tetrahydrocannabinol and methamphetamine on sustained attention in the jumping spider (Trite planiceps).

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dc.contributor.authorHumphrey , Bonnie
dc.contributor.authorGlass , Michelle
dc.contributor.authorHill , Jonathan
dc.contributor.authorOsborne , Amy J.
dc.contributor.authorStouffer , Daniel B.
dc.contributor.authorNoble , Alexandra
dc.contributor.authorHelton , William S.
dc.contributor.authorChen , Shuli
dc.contributor.authorNelson, Ximena
dc.date.accessioned2025-02-09T20:17:10Z
dc.date.available2025-02-09T20:17:10Z
dc.date.issued2024
dc.description.abstractDecreasing responsiveness to repeated visual stimuli (i.e., the inability to sustain attention) in jumping spiders (Salticidae) parallels that found in humans. In humans, drugs affect vigilance, and previous work on salticids has shown that the “vigilance decrement” is unlikely to be sensory habituation and that caffeine ameliorates reductions in attention. We exposed Trite planiceps to delta-9 tetrahydrocannabinol (THC) and methamphetamine before presenting them with a repeated visual stimulus. In the THC experiment, spiders were given a THC solution, water, or a vehicle solution, using a within-subjects design. The orienting response (i.e., “interest”) of salticids on a track ball to face a fly stimulus presented peripherally on a monitor was scored, as well as “general movement” (e.g., walking, as a control for physical fatigue) and “no movement.” The methamphetamine experiment was identical except that salticids were given methamphetamine solution or water. In both the THC and methamphetamine treatments, general movement dropped over time, while in control treatments, this was constant. Additionally, due to an initial stimulating effect of methamphetamine on interest, the response decrement was significantly steeper when spiders were administered methamphetamine compared with water. Our results suggest that the modulation of sustained attention, and possibly motivation, is likely in salticids. basic local alignment search tool genome queries on a closely related species and pharmacological radioligand experiments suggested that salticids do not possess cannabinoid receptors, but the presence of transient receptor potential proteins may help explain the small behav ioral changes observed with THC. In contrast, how methamphetamine affects salticids remains unknown
dc.identifier.citationHumphrey B, Glass M, Hill J, Osborne AJ, Stouffer DB, Noble A, Helton WS, Chen S, Nelson XJ The effect of delta-9 tetrahydrocannabinol and methamphetamine on sustained attention in the jumping spider (Trite planiceps).. Journal of Comparative Psychology.
dc.identifier.doihttp://doi.org/10.1037/com0000396
dc.identifier.issn0735-7036
dc.identifier.issn1939-2087
dc.identifier.urihttps://hdl.handle.net/10092/107907
dc.languageen
dc.publisherAmerican Psychological Association (APA)
dc.rightsThis article is published under a CC BY license. The reader is expected to respect the intellectual property of the author and to provide appropriate credit if the content is reused.
dc.rights.urihttp://hdl.handle.net/10092/17651
dc.subjectresponse decrement
dc.subjecthabituation
dc.subjectpharmacological study
dc.subjectcognition
dc.subjectlearning
dc.subject.anzsrc31 - Biological sciences::3109 - Zoology::310901 - Animal behaviour
dc.subject.anzsrc52 - Psychology::5204 - Cognitive and computational psychology::520401 - Cognition
dc.titleThe effect of delta-9 tetrahydrocannabinol and methamphetamine on sustained attention in the jumping spider (Trite planiceps).
dc.typeJournal Article
uc.collegeFaculty of Science
uc.departmentSchool of Biological Sciences
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