Development of Blood Glucose Control for Extremely Premature Infants

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dc.contributor.authorLe Compte, A.J.
dc.contributor.authorChase, Geoff
dc.contributor.authorLynn, A.
dc.contributor.authorHann, C.E.
dc.contributor.authorShaw, Geoff
dc.contributor.authorLin, J.
dc.date.accessioned2012-02-27T22:30:47Z
dc.date.available2012-02-27T22:30:47Z
dc.date.issued2011en
dc.description.abstractExtremely premature neonates often experience hyperglycaemia, which has been linked to increased mortality and worsened outcomes. Insulin therapy can assist in controlling blood glucose levels and promoting needed growth. This study presents the development of a model-based stochastic targeted controller designed to adapt insulin infusion rates to match the unique and changing metabolic state and control parameters of the neonate. Long-term usage of targeted BG control requires successfully forecasting variations in neonatal metabolic state, accounting for differences in clinical practices between units, and demonstrating robustness to errors that can occur in everyday clinical usage. Simulation studies were used to evaluate controller ability to target several common BG ranges and evaluate controller sensitivity to missed BG measurements and delays in control interventions on a virtual patient cohort of 25 infants developed from retrospective data. Initial clinical pilot trials indicated model performance matched expected performance from simulations. Stochastic targeted glucose control developed using validated patient-specific virtual trials can yield effective protocols for this cohort. Long-term trials show fundamental success, however clinical interface design appears as a critical factor to ensuring good compliance and thus good control.en
dc.identifier.citationLeCompte, A.J., Chase, J.G., Lynn, A., Hann, C.E., Shaw, G.M., Lin, J. (2011) Development of Blood Glucose Control for Extremely Premature Infants. Computer Methods and Programs in Biomedicine, 102(2), pp. 181-191.en
dc.identifier.doihttps://doi.org/10.1016/j.cmpb.2010.03.010
dc.identifier.issn0169-2607
dc.identifier.urihttp://hdl.handle.net/10092/6329
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineeringen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectGlucoseen
dc.subjectsimulationen
dc.subjectinsulinen
dc.subjectcontrolen
dc.subjectreal-timeen
dc.subjectneonateen
dc.subjectuser interface.en
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320212 - Intensive careen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinologyen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320102 - Haematologyen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineeringen
dc.titleDevelopment of Blood Glucose Control for Extremely Premature Infantsen
dc.typeJournal Article
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