Single-patient multiple crossover studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study

Type of content
Journal Article
Thesis discipline
Degree name
Publisher
University of Canterbury. School of Health Sciences
Journal Title
Journal ISSN
Volume Title
Language
Date
2016
Authors
Nikles, J.
Mitchell, G.K.
Hardy, J.
Senior, H.
Carmont, S.A.
Schluter, P.J.
Vora, R.
Currow, D.
Yelland, M.
Abstract

Paracetamol is a useful adjunct when used in combination with “weak opioids” for chronic pain in palliative care patients with advanced cancer, however it is not certain that there is continuing benefit when used in conjunction with “strong” opioids. N-of-1 trials allowed individual treatment decisions to be made for each participant: there was no added benefit for any of the participants, although no conclusion about the added benefit of paracetamol above regular opioids was possible for the group, due to insufficient numbers recruited. Paracetamol may not provide added benefit above regular opioids; this should assessed on a case by case basis to justify the extra tablet load.

Description
Citation
Nikles, J., Mitchell, G.K., Hardy, J., Senior, H., Carmont, S.A., Schluter, P.J., Vora, R., Currow, D., Yelland, M. (2016) Single-patient multiple crossover studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: A pilot study. Palliative Medicine, 30(8), pp. 800-802.
Keywords
paracetamol, n-of-1 trial, palliative care, pain, opioids
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Fields of Research::32 - Biomedical and clinical sciences::3214 - Pharmacology and pharmaceutical sciences::321402 - Clinical pharmacology and therapeutics
Fields of Research::32 - Biomedical and clinical sciences::3211 - Oncology and carcinogenesis::321104 - Cancer therapy (excl. chemotherapy and radiation therapy)
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