P-TEFb: finding its ways to release promoter-proximally paused RNA Polymerase II
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Journal Article
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Date
2017
Authors
Li Y
Liu M
Chen L-F
Chen R
Abstract
The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.
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Citation
Li Y, Liu M, Chen L-F, Chen R (2017). P-TEFb: finding its ways to release promoter-proximally paused RNA Polymerase II. Transcription. 00-00.
Keywords
P-TEFb, 7SK snRNP, Brd4, SEC, KAP1, RNA Pol II, promoter-proximal pausing, transcription elongation
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ANZSRC fields of research
Field of Research::06 - Biological Sciences::0601 - Biochemistry and Cell Biology