P-TEFb: finding its ways to release promoter-proximally paused RNA Polymerase II

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Journal Article
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Degree name
Publisher
Journal Title
Journal ISSN
Volume Title
Language
Date
2017
Authors
Li Y
Liu M
Chen L-F
Chen R
Abstract

The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.

Description
Citation
Li Y, Liu M, Chen L-F, Chen R (2017). P-TEFb: finding its ways to release promoter-proximally paused RNA Polymerase II. Transcription. 00-00.
Keywords
P-TEFb, 7SK snRNP, Brd4, SEC, KAP1, RNA Pol II, promoter-proximal pausing, transcription elongation
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Field of Research::06 - Biological Sciences::0601 - Biochemistry and Cell Biology
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