Micro- and Nanopatterning of Freestanding Protein Films (2015)
Type of ContentConference Contributions - Other
PublisherUniversity of Canterbury. Electrical and Computer Engineering
University of Canterbury. Biomolecular Interaction Centre
AuthorsHashemi, A., Tay, D., Mutreja, I., Ali, M.A., Alkaisi, M.M., Nock, V.show all
Biodegradable casein films have significant potential for use as non-supported stand-alone sheeting in orthopaedic implants and tissue engineering substrates. Multi-scale surface patterns can be used to modulate and guide cell interaction by means of an engineered construct. The majority of work on cell-pattern interaction has so far focused on non-degradable materials. In this paper we demonstrate for the first time the fabrication of micro- and nano-scale geometric patterns on the surface of a crosslinked biodegradable casein film. To achieve this we introduce a two-step fabrication procedure based on polydimethylsiloxane (PDMS) soft-lithography. We will show the reproduction of micro- and nano-scale patterns in liquid-cast casein films. We also demonstrate film formation and cross-linking using glutaraldehyde and discuss the use of these films as cell-culture substrates.
CitationHashemi, A., Tay, D., Mutreja, I., Ali, M.A., Alkaisi, M.M., Nock, V. (2015) Micro- and Nanopatterning of Freestanding Protein Films. Nelson, New Zealand: 7th International Conference on Nanotechnology and Advanced Materials (AMN-7), 8-12 Feb 2015.
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ANZSRC Fields of Research10 - Technology::1004 - Medical Biotechnology::100404 - Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
10 - Technology::1007 - Nanotechnology::100706 - Nanofabrication, Growth and Self Assembly