Micro- and Nanopatterning of Freestanding Protein Films

Type of content
Conference Contributions - Other
Publisher's DOI/URI
Thesis discipline
Degree name
Publisher
University of Canterbury. Electrical and Computer Engineering
University of Canterbury. Biomolecular Interaction Centre
Journal Title
Journal ISSN
Volume Title
Language
Date
2015
Authors
Hashemi, A.
Tay, D.
Mutreja, I.
Ali, M.A.
Alkaisi, M.M.
Nock, V.
Abstract

Biodegradable casein films have significant potential for use as non-supported stand-alone sheeting in orthopaedic implants and tissue engineering substrates. Multi-scale surface patterns can be used to modulate and guide cell interaction by means of an engineered construct. The majority of work on cell-pattern interaction has so far focused on non-degradable materials. In this paper we demonstrate for the first time the fabrication of micro- and nano-scale geometric patterns on the surface of a crosslinked biodegradable casein film. To achieve this we introduce a two-step fabrication procedure based on polydimethylsiloxane (PDMS) soft-lithography. We will show the reproduction of micro- and nano-scale patterns in liquid-cast casein films. We also demonstrate film formation and cross-linking using glutaraldehyde and discuss the use of these films as cell-culture substrates.

Description
Citation
Hashemi, A., Tay, D., Mutreja, I., Ali, M.A., Alkaisi, M.M., Nock, V. (2015) Micro- and Nanopatterning of Freestanding Protein Films. Nelson, New Zealand: 7th International Conference on Nanotechnology and Advanced Materials (AMN-7), 8-12 Feb 2015.
Keywords
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Field of Research::10 - Technology::1004 - Medical Biotechnology::100404 - Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Fields of Research::40 - Engineering::4018 - Nanotechnology::401805 - Nanofabrication, growth and self assembly
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