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    Identifying pressure dependent elastance in lung mechanics with reduced influence of unmodelled effects

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    Author
    Laufer, B.
    Docherty, P.D.
    Chiew, Y.S.
    Moeller, K.
    Chase, J.G.
    Date
    2015
    Permanent Link
    http://hdl.handle.net/10092/11251

    The selection of optimal positive end expiratory pressure (PEEP) levels during ventilation therapy of patients with ARDS (acute respiratory distress syndrome) remains a problem for clinicians. One particular mooted strategy states that minimizing the energy transferred to the lung by mechanical ventilation could potentially be used to determine the optimal PEEP level. This minimization could potentially be undertaken by finding the minimum range of dynamic elastance. In this study, we compare an adapted Gauss-Newton method with the typical gauss newton method in terms of the level of agreement obtained in elastance-pressure curves across different PEEP levels in 10 patients. The Gauss-Newton adaptation effectively ignored characteristics in the data that are un-modelled. The adapted method successfully determined regions of the data that were un-modelled, as expected. In ignoring this un-modelled behavior, the adapted method captured the desired elastance-pressure curves with more consistency than the typical least-squares Gauss Newton method.

    Subjects
    Gauss-Newton,
     
    Physiological Modeling
     
    First order model
     
    Mechanical Ventilation
     
    Field of Research::09 - Engineering::0903 - Biomedical Engineering::090302 - Biomechanical Engineering
    Collections
    • Engineering: Conference Contributions [1920]
    Rights
    https://canterbury.libguides.com/rights/ir

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