University of Canterbury Home
    • Admin
    UC Research Repository
    UC Library
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    1. UC Home
    2. Library
    3. UC Research Repository
    4. Faculty of Engineering | Te Kaupeka Pūhanga
    5. Engineering: Journal Articles
    6. View Item
    1. UC Home
    2.  > 
    3. Library
    4.  > 
    5. UC Research Repository
    6.  > 
    7. Faculty of Engineering | Te Kaupeka Pūhanga
    8.  > 
    9. Engineering: Journal Articles
    10.  > 
    11. View Item

    Hyperglycaemic preterm babies have sex differences in insulin secretion (2015)

    Thumbnail
    View/Open
    12655184_Hyperglycaemic preterm babies have sex differences in insulin secretion.pdf (361.5Kb)
    Type of Content
    Journal Article
    UC Permalink
    http://hdl.handle.net/10092/10958
    
    Publisher's DOI/URI
    https://doi.org/10.1159/000381206
    
    Publisher
    University of Canterbury. Mechanical Engineering
    Collections
    • Engineering: Journal Articles [1636]
    Authors
    Dickson, J.L.
    Chase, Geoff cc
    Pretty, C.G.
    Gunn, C.A.
    Alsweiler, J.A.
    show all
    Abstract

    Background: Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. Objective: To determine insulin secretion calculated from plasma C-peptide concentrations in hyperglycaemic preterm babies. Methods: A retrospective analysis of a cohort of 41 very preterm babies (median gestational age, weeks: 27.2 (26.2-28.7)) enrolled in a randomised controlled trial of tight glycaemic control when they developed hyperglycaemia (2 consecutive blood glucose concentrations (BGC) > 8.5 mmol.L-1). Insulin secretion was determined using a steady state analysis of a 2 compartment C-peptide kinetic model. Results: BGC, plasma insulin concentration, plasma C-peptide concentrations and insulin secretion were higher at randomisation than 1-2 weeks following randomisation (p≤0.02). Insulin secretion was higher in girls (11.7 (5.3-18.7) vs. 4.7 (2.1-8.3) mU.L-1.kg-1.min-1, p<0.005) with no difference in clinical characteristics, BGC, plasma insulin concentration, or nutrition between the sexes (p>0.25). Insulin secretion was lower in samples taken during exogenous insulin delivery (3.7 (1.8 - 6.9) vs. 9.8 (4.7 - 17.8) mU.L-1.kg-1.min-1, p=0.02). Conclusions: Insulin secretion was higher when babies had higher BGC, indicating endogenous insulin secretion is sensitive to BGC. Girls had higher insulin secretion, at similar blood glucose and plasma insulin concentrations, than boys.

    Citation
    Dickson, J.L., Chase, J.G., Pretty, C.G., Gunn, C.A., Alsweiler, J.A. (2015) Hyperglycaemic preterm babies have sex differences in insulin secretion. Neonatology, 108(2), pp. 93-98.
    This citation is automatically generated and may be unreliable. Use as a guide only.
    Keywords
    preterm; hyperglycaemia; insulin secretion; sexual dimorphism
    ANZSRC Fields of Research
    40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering
    10 - Technology::1004 - Medical Biotechnology
    Rights
    https://hdl.handle.net/10092/17651

    Related items

    Showing items related by title, author, creator and subject.

    • A C-Peptide-Based Model of Pancreatic Insulin Secretion in Extremely Preterm Neonates in Intensive Care 

      Dickson, J.L.; Alsweiler, J.; Gunn, C.A.; Pretty, C.G.; Chase, Geoff (University of Canterbury. Mechanical Engineering, 2016)
      Background: Model-based glycaemic control relies on sufficiency of underlying models to describe underlying patient physiology. In particular, very preterm infant glucose-insulin metabolism can differ significantly from ...
    • Endogenous insulin secretion and suppression during and after sepsis in critically ill patients – implications for TGC protocols 

      Pretty, C.G.; Docherty, P.D.; Pfeiffer, L.; Jamaludin, U.; Shaw, Geoff; Le Compte, A.J.; Chase, Geoff (University of Canterbury. Mechanical Engineering, 2011)
      Introduction: Insulin infusions over 2 U/hr can suppress endogenous insulin secretion in healthy subjects 30-45% [1]. Virtually all tight glycaemic control (TGC) protocols deliver insulin via infusion. This study examines ...
    • Impact of glucocorticoids on insulin resistance in the critically ill 

      Pretty, C.G.; Chase, Geoff; Lin, J.; Shaw, Geoff; Le Compte, A.J.; Razak, N.; Parente, J.D. (University of Canterbury. Mathematics and StatisticsUniversity of Canterbury. Mechanical Engineering, 2011)
      Glucocorticoids (GCs) have been shown to reduce insulin sensitivity in healthy individuals. Widely used in critical care to treat a variety of inflammatory and allergic disorders, they may inadvertently exacerbate ...
    Advanced Search

    Browse

    All of the RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThesis DisciplineThis CollectionBy Issue DateAuthorsTitlesSubjectsThesis Discipline

    Statistics

    View Usage Statistics
    • SUBMISSIONS
    • Research Outputs
    • UC Theses
    • CONTACTS
    • Send Feedback
    • +64 3 369 3853
    • ucresearchrepository@canterbury.ac.nz
    • ABOUT
    • UC Research Repository Guide
    • Copyright and Disclaimer
    • SUBMISSIONS
    • Research Outputs
    • UC Theses
    • CONTACTS
    • Send Feedback
    • +64 3 369 3853
    • ucresearchrepository@canterbury.ac.nz
    • ABOUT
    • UC Research Repository Guide
    • Copyright and Disclaimer