Hyperglycaemic preterm babies have sex differences in insulin secretion

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dc.contributor.authorDickson, J.L.
dc.contributor.authorChase, Geoff
dc.contributor.authorPretty, C.G.
dc.contributor.authorGunn, C.A.
dc.contributor.authorAlsweiler, J.A.
dc.date.accessioned2015-09-27T23:41:00Z
dc.date.available2015-09-27T23:41:00Z
dc.date.issued2015en
dc.description.abstractBackground: Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. Objective: To determine insulin secretion calculated from plasma C-peptide concentrations in hyperglycaemic preterm babies. Methods: A retrospective analysis of a cohort of 41 very preterm babies (median gestational age, weeks: 27.2 (26.2-28.7)) enrolled in a randomised controlled trial of tight glycaemic control when they developed hyperglycaemia (2 consecutive blood glucose concentrations (BGC) > 8.5 mmol.L-1). Insulin secretion was determined using a steady state analysis of a 2 compartment C-peptide kinetic model. Results: BGC, plasma insulin concentration, plasma C-peptide concentrations and insulin secretion were higher at randomisation than 1-2 weeks following randomisation (p≤0.02). Insulin secretion was higher in girls (11.7 (5.3-18.7) vs. 4.7 (2.1-8.3) mU.L-1.kg-1.min-1, p<0.005) with no difference in clinical characteristics, BGC, plasma insulin concentration, or nutrition between the sexes (p>0.25). Insulin secretion was lower in samples taken during exogenous insulin delivery (3.7 (1.8 - 6.9) vs. 9.8 (4.7 - 17.8) mU.L-1.kg-1.min-1, p=0.02). Conclusions: Insulin secretion was higher when babies had higher BGC, indicating endogenous insulin secretion is sensitive to BGC. Girls had higher insulin secretion, at similar blood glucose and plasma insulin concentrations, than boys.en
dc.identifier.citationDickson, J.L., Chase, J.G., Pretty, C.G., Gunn, C.A., Alsweiler, J.A. (2015) Hyperglycaemic preterm babies have sex differences in insulin secretion. Neonatology, 108(2), pp. 93-98.en
dc.identifier.doihttps://doi.org/10.1159/000381206
dc.identifier.urihttp://hdl.handle.net/10092/10958
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineeringen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectpretermen
dc.subjecthyperglycaemiaen
dc.subjectinsulin secretionen
dc.subjectsexual dimorphismen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineeringen
dc.subject.anzsrcField of Research::10 - Technology::1004 - Medical Biotechnologyen
dc.titleHyperglycaemic preterm babies have sex differences in insulin secretionen
dc.typeJournal Article
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