Biomolecular Interaction Centre

Three sites and you are out: Ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis.

Blackmore, N.J.; Reichau, S.; Jiao, W.; Hutton, R.D.; Baker, E.N.; Jameson, G.B.; Parker, E.J. (University of Canterbury. Biomolecular Interaction Centre, 2013)

3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) catalyzes the first step in the shikimate pathway, the pathway responsible for the biosynthesis of the aromatic amino acids Trp, Phe, and Tyr. Unlike many ...