Randomised controlled pilot trial of an exercise plus behaviour change intervention in people with multiple sclerosis: the Step it Up study.

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dc.contributor.authorHayes S
dc.contributor.authorUszynski MK
dc.contributor.authorMotl RW
dc.contributor.authorGallagher S
dc.contributor.authorLarkin A
dc.contributor.authorNewell J
dc.contributor.authorScarrott C
dc.contributor.authorCoote S
dc.date.accessioned2018-04-23T23:04:20Z
dc.date.available2018-04-23T23:04:20Z
dc.date.issued2017en
dc.date.updated2017-10-29T09:01:26Z
dc.description.abstractTo investigate feasibility of multiple sclerosis (MS) exercise guidelines for inactive people with MS (PwMS) and to examine preliminary efficacy for walking. To investigate effect of augmenting that intervention with education based on social cognitive theory (SCT).Pilot multicentre, double-blind, randomised, parallel, controlled trial.Community-delivered programme.Sixty-five physically inactive PwMS walked independently, scored 0-3 on the Patient Determined Disease Steps Scale, had no MS relapse or change in MS medication in 12 weeks.10-week exercise plus SCT education (SCT) compared with exercise plus attention control education (CON).Six-Minute Walk Test (6MWT), Timed Up and Go (TUG) test and Multiple Sclerosis Walking Scale-12 (MSWS-12).174 expressed interest, 92 were eligible and 65 enrolled (SCT, n=32; CON, n=33). The intervention was feasible and delivered as intended. 68% of SCT group and 50% of control group met the exercise guidelines after intervention. Using linear mixed effects models, intention-to-treat basis, there was insufficient evidence for difference between the groups over the trial (6MWT, p=0.30; TUG, p=0.4; MSWS-12, p=0.8). Using secondary analysis of a cohort with data for≥3 assessments (SCT, n=21; CON, n=20), there was significant treatment effect favouring the intervention group (p=0.04) with mean effect for 6MWT 39.0 m (95% CI 2.26 to 75.73) at 12 weeks and 40.0 m (95% CI 2.3 to 77.8) at 36 weeks. Both groups improved significantly in 6MWT following 10-week intervention (SCT, mean ∆=83.02, SD=60.1, p≤0.01; CON, mean ∆=56.92, SD=73.5, p≤0.01), TUG (SCT, ∆=-0.70, SD=1.25, p≤0.01; CON, ∆=-0.54, SD=0.95, p≤0.01) and MSWS-12 (SCT, ∆=-8.03, SD=16.18, p=0.02; CON, ∆=-0.86, SD=18.74, p=0.81).A 10-week exercise programme based on the MS exercise guidelines for improving walking in previously inactive PwMS was feasible. There is marginal evidence of a treatment effect in favour of the exercise plus SCT intervention at 12 and 36 weeks.NCT02301442; Results.en
dc.identifier.citationHayes S, Uszynski MK, Motl RW, Gallagher S, Larkin A, Newell J, Scarrott C, Coote S (2017). Randomised controlled pilot trial of an exercise plus behaviour change intervention in people with multiple sclerosis: the Step it Up study.. BMJ open. 7(10). e016336-.en
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2017-016336
dc.identifier.issn2044-6055
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/10092/15211
dc.languageEnglish
dc.language.isoen
dc.subjectbehaviour changeen
dc.subjectexerciseen
dc.subjectmultiple sclerosisen
dc.subjectsocial cognitive theoryen
dc.subjectwalking mobilityen
dc.subject.anzsrcFields of Research::49 - Mathematical sciences::4901 - Applied mathematics::490102 - Biological mathematicsen
dc.subject.anzsrcField of Research::11 - Medical and Health Sciences::1109 - Neurosciences::110904 - Neurology and Neuromuscular Diseasesen
dc.titleRandomised controlled pilot trial of an exercise plus behaviour change intervention in people with multiple sclerosis: the Step it Up study.en
dc.typeJournal Articleen
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