The chemistry of complex ion anti-tumour agents
| dc.contributor.author | Miller, Sian Elisabeth | |
| dc.date.accessioned | 2017-01-09T22:32:03Z | |
| dc.date.available | 2017-01-09T22:32:03Z | |
| dc.date.issued | 1991 | en |
| dc.description.abstract | Reported here is a study of the solution chemistry of the anti-cancer drug cis-dichloro-diammineplatinum(II), cis-[PtCl₂(NH₃)₂]. In view of uncertainties in literature values of rate constants and in reaction conditions for the reactions of cis-[PtCl₂(NH₃)₂], the kinetics of the first acid hydrolysis step of cis-[PtCl₂(NH₃)₂] are reinvestigated in HClO₄ media, as well as the kinetics of the second hydrolysis step. All the kinetic investigations in this thesis are made using a DMS100 UV - visible spectrophotometer, using the changes in absorbance to monitor reactions. The nature and rate constants for the hydrolysis of cis-[PtCl₂(NH₃)₂] and the anation kinetics of the products under a variety of pH and ionic strength conditions are investigated, such as the kinetics of the base hydrolysis of cis-[PtCl₂(NH₃)₂] and its rates of hydrolysis over a wide pH range. The kinetics of the reactions of some of these hydrolysis products with a variety of ligands, some physiologically relevant and some not, such as chloride ions, sodium hydrogen malonate, glycine and ortho-phenylenediamine, are also investigated. In order to model the situation in vivo as closely as possible, a technique involving the combination of the UV - visible spectrophotometer with a pH-stat is used extensively. This enables the pH to be kept constant while a reaction in progress is being monitored. The likely distribution of platinum(II) species present in blood plasma and inside a cell is thus calculated as a result of these investigations. A possible role for metal ions in accelerating both the acid and base hydrolyses of cis-[PtCl₂(NH₃)₂] is investigated, although metal ions found in vivo are found to have no effect. The crystal structure of the product of the reaction between cis-[PtCl₂(NH₃)₂] and HgCl₂ is reported. The effect of mixtures of aqueous and non-aqueous solvents on the rate of hydrolysis of cis-[PtCl₂(NH₃)₂] was investigated as well as the kinetics of the first acid hydrolysis step of cis-[PtBr₂(NH₃)₂] and the bromide anation of cis [PtBr(NH₃)₂(OH₂)]+. As a result of this experimental work, attempts were made to extrapolate the results of these kinetic investigations, all carried out under stringent reaction conditions, to the possible reactions of cis-[PtCl₂(NH₃)₂] in vivo. | en |
| dc.identifier.uri | http://hdl.handle.net/10092/13029 | |
| dc.identifier.uri | http://dx.doi.org/10.26021/9016 | |
| dc.language | English | |
| dc.language.iso | en | |
| dc.publisher | University of Canterbury | en |
| dc.rights | All Rights Reserved | en |
| dc.rights.uri | https://canterbury.libguides.com/rights/theses | en |
| dc.title | The chemistry of complex ion anti-tumour agents | en |
| dc.type | Theses / Dissertations | |
| thesis.degree.discipline | Chemistry | en |
| thesis.degree.grantor | University of Canterbury | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |
| uc.bibnumber | 338167 | en |
| uc.college | Faculty of Science | en |