Development of a Discrete Spectrometric NIR Reflectance Glucometer

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dc.contributor.authorCampbell JD
dc.contributor.authorHolder-Pearson, Lui
dc.contributor.authorBenton C
dc.contributor.authorChase, Geoff
dc.contributor.authorPretty, Christopher
dc.contributor.authorKnopp, Jennifer
dc.date.accessioned2021-06-16T01:16:29Z
dc.date.available2021-06-16T01:16:29Z
dc.date.issued2020en
dc.date.updated2021-04-20T06:32:35Z
dc.description.abstractAbstract: Currently, there are no continuous, non-invasive blood glucose monitors. With over 366 million people worldwide expected to be diagnosed as diabetic by 2030, an alternative to the current invasive methods is critical. This paper investigates the use of a discrete spectometric, NIR reflectance glucometer to detect a change in glucose concentration in solution. At each wavelength, an LED is used to emit light, and a reverse-biased LED detects light using wavelengths 660 nm, 850 nm, 940 nm, 1450 nm, 1550 nm, 1650 nm. The discharge time of a reverse-biased LED is proportional to the temporal integral of the detected light intensity. The sensor’s response to changing glucose concentration was tested in both water and porcine blood. Glucose concentration was increased by 0.5 mmol l−1 and compared with a finger stick glucometer. Each wavelength exhibited an expected change in adsorption given only an increase in glucose concentration. The inverted exponential increase in absorption is explained by Beer Lambert’s law. Wavelengths 660 nm, 850 nm and 1450 nm showed minimal change to absorption, while 940 nm, 1550 nm and 1650 nm showed considerable change in absorption. The 1550 nm LED gave the greatest increase in absorption with a 7% rise over 4.3 mmol l−1 to 20.6 mmol l−1. Ratios of absorption responses (R1550/1650, R1550/1450 and R940/850) each gave proportional increases in absorption with increasing glucose concentrations.en
dc.identifier.citationCampbell JD, Holder-Pearson L, Pretty CG, Benton C, Knopp J, Chase JG (2020). Development of a Discrete Spectrometric NIR Reflectance Glucometer. IFAC-PapersOnLine. 53(2). 15970-15975.en
dc.identifier.doihttp://doi.org/10.1016/j.ifacol.2020.12.388
dc.identifier.issn2405-8963
dc.identifier.urihttps://hdl.handle.net/10092/102051
dc.languageen
dc.language.isoen
dc.publisherElsevier BVen
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subjectdiscrete NIR spectrometryen
dc.subjectnon-invasiveen
dc.subjectglucose sensoren
dc.subjectLED-LED detectionen
dc.subjectBeer Lambert's Lawen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400308 - Medical devicesen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400305 - Biomedical instrumentationen
dc.subject.anzsrcFields of Research::40 - Engineering::4009 - Electronics, sensors and digital hardware::400909 - Photonic and electro-optical devices, sensors and systems (excl. communications)en
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinologyen
dc.titleDevelopment of a Discrete Spectrometric NIR Reflectance Glucometeren
dc.typeJournal Articleen
uc.collegeFaculty of Engineering
uc.departmentMechanical Engineering
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