Effect of small airways and viscoelasticity on lung mechanics from expiratory occlusion

Simple item page
dc.contributor.authorHowe SL
dc.contributor.authorMärz M
dc.contributor.authorKrüger-Ziolek S
dc.contributor.authorLaufer B
dc.contributor.authorPretty C
dc.contributor.authorShaw, Geoff
dc.contributor.authorDesaive T
dc.contributor.authorMöller K
dc.contributor.authorChase, Geoff
dc.date.accessioned2021-06-09T00:41:33Z
dc.date.available2021-06-09T00:41:33Z
dc.date.issued2020en
dc.date.updated2021-04-20T06:25:24Z
dc.description.abstractMonitoring the decay rate of airflow in spirometry may be clinically useful. The decay rate is expected to represent a combination of lung elastance and airway resistance. However, the decay rate calculated using the single compartment lung model is not expected to account for slower lung mechanics, such as small airways resistance and tissue viscoelasticity. This study assesses whether the decay rate is affected by these lung mechanics. An exponentially decaying flow was created using a shutter to occlude airflow during passive expiration for 15 healthy subjects. To approximate small airways resistance and viscoelasticity, the gradient of pressure increase (relaxation gradient) during shutter closure was measured. The occlusion resistance, elastance, and decay rate were also calculated for these breaths. None of these mechanics were found to be correlated with the relaxation gradient. The relaxation gradient was also found to be independent of driving pressure. Conversely, the relaxation gradient was found to depend on lung volume. The results of this study suggest using lung mechanics and decay rate to monitor changes in lung condition over time may miss information about changes in the small airways and viscoelastic lung tissue. Thus, it is useful for monitoring large airways disease, but may be ineffective for small airways disease such as ARDS.en
dc.identifier.citationHowe SL, März M, Krüger-Ziolek S, Laufer B, Pretty C, Shaw GM, Desaive T, Möller K, Chase JG (2020). Effect of small airways and viscoelasticity on lung mechanics from expiratory occlusion. IFAC-PapersOnLine. 53(2). 16251-16256.en
dc.identifier.doihttp://doi.org/10.1016/j.ifacol.2020.12.620
dc.identifier.issn2405-8963
dc.identifier.urihttps://hdl.handle.net/10092/101996
dc.languageen
dc.language.isoen
dc.publisherElsevier BVen
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subjectSpirometryen
dc.subjectmathematical modelsen
dc.subjectlungsen
dc.subjectParameter identificationen
dc.subjectrespiratory mechanicsen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320103 - Respiratory diseasesen
dc.titleEffect of small airways and viscoelasticity on lung mechanics from expiratory occlusionen
dc.typeJournal Articleen
uc.collegeFaculty of Engineering
uc.departmentMechanical Engineering
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Howe 2 small airways.pdf
Size:
994.85 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
Collections
Engineering: Journal Articles