Probing the active site of anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis to facilitate novel drug development
| dc.contributor.author | Cookson, Tammie Violet Marie | |
| dc.date.accessioned | 2014-04-01T22:11:20Z | |
| dc.date.available | 2015-04-02T11:20:04Z | |
| dc.date.issued | 2013 | en |
| dc.description.abstract | Caused by the organism Mycobacterium tuberculosis (Mtu), the globally distributed disease tuberculosis was responsible for the deaths of 1.4 million people in 2011. Anthranilate phosphoribosyltransferase (AnPRT) is an enzyme that catalyses the second committed step of the tryptophan biosynthetic pathway within Mtu, and is a promising target for antibiotics. This research aimed to further understand the mechanics of the AnPRT active site, in order to provide useful information towards AnPRT drug design. AnPRT inhibition and alternate substrates were investigated as well as variant AnPRT proteins, the results of which aided in unravelling a complex active site mechanism and illuminating several decisive inhibition strategies. | en |
| dc.identifier.uri | http://hdl.handle.net/10092/9049 | |
| dc.identifier.uri | http://dx.doi.org/10.26021/8431 | |
| dc.language.iso | en | |
| dc.publisher | University of Canterbury. Chemistry | en |
| dc.relation.isreferencedby | NZCU | en |
| dc.rights | Copyright Tammie Violet Marie Cookson | en |
| dc.rights.uri | https://canterbury.libguides.com/rights/theses | en |
| dc.subject | AnPRT | en |
| dc.subject | tryptophan biosynthesis | en |
| dc.subject | drug design | en |
| dc.subject | tuberculosis | en |
| dc.subject | anthranilate | en |
| dc.subject | PRPP | en |
| dc.title | Probing the active site of anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis to facilitate novel drug development | en |
| dc.type | Theses / Dissertations | |
| thesis.degree.discipline | Chemistry | en |
| thesis.degree.grantor | University of Canterbury | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |
| uc.bibnumber | 1994976 | en |
| uc.college | Faculty of Science | en |
| uc.embargo | 12 | en |