Coronary smooth muscle cell calcium dynamics: Effects of bifurcation angle on atheroprone conditions

Simple item page
dc.contributor.authorDowding S
dc.contributor.authorZakkaroff C
dc.contributor.authorMoore S
dc.contributor.authorDavid T
dc.date.accessioned2019-02-03T22:18:22Z
dc.date.available2019-02-03T22:18:22Z
dc.date.issued2018en
dc.date.updated2019-01-28T22:37:44Z
dc.description.abstract© 2018 Frontiers Media S.A.All right reserved. This work investigates the effect of arterial bifurcation angulation on atherosclerosis development through in-silico simulations of coupled cell dynamics. The computational model presented here combines cellular pathways, fluid dynamics, and physiologically-realistic vessel geometries as observed in the human vasculature. The coupled cells model includes endothelial cells (ECs) and smooth muscle cells (SMCs) with ion dynamics, hetero and homotypic coupling, as well as electro-diffusive coupling. Three arterial bifurcation surface models were used in the coupled cells simulations. All three simulations showed propagating waves of Ca2+ in both the SMC and EC layers, following the introduction of a luminal agonist, in this case ATP. Immediately following the introduction of ATP concentration Ca2+ waves propagate from the area of high ATP toward the areas of low ATP concentration, forming complex patterns where waves interact with eachother, collide and fade. These dynamic phenomena are repeated with a series of waves of slower velocity. The underlying motivation of this research was to examine the macro-scale phenomena, given that the characteristic length scales of atherosclerotic plaques are much larger than a single cell. The micro-scale dynamics were modeled on macro-scale arterial bifurcation surfaces containing over one million cells. The results of the simulations presented here suggest that susceptibility to atherosclerosis development depends on the bifurcation angulation. In conjunction with findings reported in the literature, the simulation results demonstrate that arterial bifurcations containing wider angles have a more prominent influence on the coupled cells pathways associated with the development of atherosclerosis, by means of disturbed flow and lower SMC Ca2+ concentrations. The discussion of the results considers the findings of this research within the context of the potential link between information transport through frequency encoding of Ca2+ wave dynamics and development of atheroprone conditions.en
dc.identifier.doihttps://doi.org/10.3389/fphys.2018.01528
dc.identifier.issn1664-042X
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/10092/16441
dc.languageEnglish
dc.language.isoen
dc.rightsCopyright © 2018 Dowding, Zakkaroff, Moore and David. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectcoupled arterial cellsen
dc.subjectendothelial cellsen
dc.subjectsmooth muscle cellsen
dc.subjectatherosclerosisen
dc.subjectphysiological modelingen
dc.subjectparallel simulationsen
dc.subjectbifurcation angleen
dc.subjectcalcium dynamicsen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3208 - Medical physiology::320801 - Cell physiologyen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3208 - Medical physiology::320803 - Systems physiologyen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320101 - Cardiology (incl. cardiovascular diseases)en
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3205 - Medical biochemistry and metabolomics::320503 - Medical biochemistry - inorganic elements and compoundsen
dc.subject.anzsrcField of Research::08 - Information and Computing Sciences::0806 - Information Systems::080603 - Conceptual Modellingen
dc.titleCoronary smooth muscle cell calcium dynamics: Effects of bifurcation angle on atheroprone conditionsen
dc.typeJournal Articleen
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Coronary Smooth Muscle Cell Calcium Dynamics: Effects of Bifurcation Angle on Atheroprone Conditions.pdf
Size:
2.07 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
Collections
Business: Journal Articles