Microdevice-based mechanical compression on living cells

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dc.contributor.authorOnal, Sevgi
dc.contributor.authorAlkaisi, Maan
dc.contributor.authorNock, Volker
dc.date.accessioned2023-02-07T01:19:41Z
dc.date.available2023-02-07T01:19:41Z
dc.date.issued2022en
dc.date.updated2022-11-23T21:04:31Z
dc.description.abstractCompressive stress enables the investigation of a range of cellular processes in which forces play an important role, such as cell growth, differentiation, migration, and invasion. Such solid stress can be introduced externally to study cell response and to mechanically induce changes in cell morphology and behavior by static or dynamic compression. Microfluidics is a useful tool for this, allowing one to mimic in vivo microenvironments in on-chip culture systems where force application can be controlled spatially and temporally. Here, we review the mechanical compression applications on cells with a broad focus on studies using microtechnologies and microdevices to apply cell compression, in comparison to off-chip bulk systems. Due to their unique features, microfluidic systems developed to apply compressive forces on single cells, in 2D and 3D culture models, and compression in cancer microenvironments are emphasized. Research efforts in this field can help the development of mechanoceuticals in the future.en
dc.identifier.citationOnal S, Alkaisi MM, Nock V (2022). Microdevice-based mechanical compression on living cells. iScience. 105518-105518.en
dc.identifier.doihttp://doi.org/10.1016/j.isci.2022.105518
dc.identifier.issn2589-0042
dc.identifier.urihttps://hdl.handle.net/10092/105093
dc.languageen
dc.language.isoenen
dc.publisherElsevier BVen
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subject.anzsrcFields of Research::31 - Biological sciences::3101 - Biochemistry and cell biology::310105 - Cellular interactions (incl. adhesion, matrix, cell wall)en
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineeringen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400307 - Mechanobiologyen
dc.subject.anzsrcFields of Research::40 - Engineering::4012 - Fluid mechanics and thermal engineering::401210 - Microfluidics and nanofluidicsen
dc.titleMicrodevice-based mechanical compression on living cellsen
dc.typeJournal Articleen
uc.collegeFaculty of Engineering
uc.departmentElectrical and Computer Engineering
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