Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration

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dc.contributor.authorStarfinger, C.
dc.contributor.authorChase, Geoff
dc.contributor.authorHann, C.E.
dc.contributor.authorShaw, Geoff
dc.contributor.authorLambermont, B.
dc.contributor.authorGhuysen, A.
dc.contributor.authorKolh, P.
dc.contributor.authorDauby, P.C.
dc.contributor.authorDesaive, T.
dc.date.accessioned2009-03-29T19:35:38Z
dc.date.available2009-03-29T19:35:38Z
dc.date.issued2008en
dc.description.abstractA previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N = 6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.en
dc.identifier.citationStarfinger, C., Chase, J.G., Hann, C.E., Shaw, G.M., Lambermont, B., Ghuysen, A., Kolh, P., Dauby, P.C., Desaive, T. (2008) Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration. Mathematical Biosciences, 216(2), pp. 132-139.en
dc.identifier.doihttps://doi.org/10.1016/j.mbs.2008.08.014
dc.identifier.issn0018-9294
dc.identifier.urihttp://hdl.handle.net/10092/2243
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineering.en
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectCardiovascular systemen
dc.subjectCardiac modelen
dc.subjectParameter identificationen
dc.subjectIntegral methoden
dc.subjectEndotoxinen
dc.subjectHemofiltrationen
dc.subjectSeptic shocken
dc.subject.marsdenFields of Research::290000 Engineering and Technology::291500 Biomedical Engineeringen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::329900 Other Medical and Health Sciences::329902 Medical biotechnologyen
dc.titleModel-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltrationen
dc.typeJournal Article
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