Enhanced pattern resolution, swelling-behaviour and biocompatibility of bioimprinted casein microdevices

Simple item page
dc.contributor.authorHashemi A
dc.contributor.authorde Decker F
dc.contributor.authorAlkaisi, Maan
dc.contributor.authorAli MA
dc.contributor.authorOrcheston-Findlay L
dc.contributor.authorNock, Volker
dc.date.accessioned2018-12-09T19:48:58Z
dc.date.available2018-12-09T19:48:58Z
dc.date.issued2017en
dc.date.updated2017-11-20T19:48:40Z
dc.description.abstractThis work introduces casein microstructures with surface features as a biodegradable biomedical platform technology for enhancing tissue-engineering applications. An optimized fabrication process is presented to reduce the hydrophobicity of intermediate polydimethylsiloxane (PDMS) molds and to transfer high-resolution regular and biomimetic features onto the surface of casein devices. Four different cross-linking reagents, glutaraldehyde, formaldehyde, citric acid and transglutaminase(TG) were investigated to increase the degradation time of casein and their influence on swelling and biocompatibility of the films was studied. TG was found to be the only cross-linker to effectively increase the degradation time and show reduced film swelling after immersion into media, while remaining compatible with cell-culture. The maximum expansion of the films cross-linked via TG was 33% after 24 hours of immersion in cell-culture media. C2C12 cells were successfully cultured on the patterned films for up to 72 hours. The patterned biodegradable casein substrates presented here have promising applications in stem-cell engineering, regenerative medicine, and implantable devices.en
dc.identifier.doihttps://doi.org/10.1063/1.4991783
dc.identifier.issn2158-3226
dc.identifier.urihttp://hdl.handle.net/10092/16314
dc.language.isoen
dc.rightsAll article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subject.anzsrcField of Research::09 - Engineering::0903 - Biomedical Engineeringen
dc.titleEnhanced pattern resolution, swelling-behaviour and biocompatibility of bioimprinted casein microdevicesen
dc.typeJournal Articleen
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Paper_EnhancedPattResSwellBiocompBioimpCaseinMicrodev_Hashemi_AIPAdv(2017).pdf
Size:
1.4 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
Collections
Engineering: Journal Articles