Prediction of hemodynamic changes towards PEEP titrations at different volemic levels using a minimal cardiovascular model.

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dc.contributor.authorStarfinger, C.
dc.contributor.authorChase, Geoff
dc.contributor.authorHann, C.E.
dc.contributor.authorShaw, Geoff
dc.contributor.authorLambert, P.
dc.contributor.authorSmith, B.W.
dc.contributor.authorSloth, E.
dc.contributor.authorLarsson, A.
dc.contributor.authorAndreassen, S.
dc.contributor.authorRees, S.
dc.date.accessioned2009-04-15T00:26:58Z
dc.date.available2009-04-15T00:26:58Z
dc.date.issued2008en
dc.description.abstractA cardiovascular system model and parameter identification method have previously been validated for porcine experiments of induced pulmonary embolism and positive end-expiratory pressure (PEEP) titrations, accurately tracking all the main hemodynamic trends. In this research, the model and parameter identification process are further validated by predicting the effect of intervention. An overall population-specific rule linking specific model parameters to increases in PEEP is formulated to predict the hemodynamic effects on arterial pressure, pulmonary artery pressure and stroke volume. Hemodynamic changes are predicted for an increase from 0 to 10cmH₂O with median absolute percentage errors less than 7% (systolic pressures) and 13% (stroke volume). For an increase from 10 to 20cmH₂O median absolute percentage errors are less than 11% (systolic pressures) and 17% (stroke volume). These results validate the general applicability of such a rule, which is not pig-specific, but holds over for all analyzed pigs. This rule enables physiological simulation and prediction of patient response. Overall, the prediction accuracy achieved represents a further clinical validation of these models, methods and overall approach to cardiovascular diagnosis and therapy guidance.en
dc.identifier.citationStarfinger, C., Chase, J.G., Hann, C.E., Shaw, G.M., Lambert, P., Smith, B.W., Sloth, E., Larsson, A., Andreassen, S., Rees, S. (2008) Prediction of hemodynamic changes towards PEEP titrations at different volemic levels using a minimal cardiovascular model.. Computer Methods and Programs in Biomedicine, 91(2), pp. 128-134.en
dc.identifier.doihttps://doi.org/10.1016/j.cmpb.2008.03.004
dc.identifier.issn0169-2607
dc.identifier.urihttp://hdl.handle.net/10092/2301
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineering.en
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectcardiovascular systemen
dc.subjectcardiac modelen
dc.subjectparameter identificationen
dc.subjectintegral methoden
dc.subjectPEEPen
dc.subjecthypovolemiaen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321003 Cardiology (incl. cardiovascular disease)en
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::320600 Medical Physiology::320603 Systems physiologyen
dc.titlePrediction of hemodynamic changes towards PEEP titrations at different volemic levels using a minimal cardiovascular model.en
dc.typeJournal Article
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