Insulin pump accuracy at low and minimum delivery rates, in relation to paediatric diabetes care

Type of content
Conference Contributions - Published
Thesis discipline
Degree name
Publisher
Elsevier BV
Journal Title
Journal ISSN
Volume Title
Language
Date
2023
Authors
Payne , Matthew
Pooke , Francis
Holder-Pearson, Lui
Chase, Geoff
Abstract

Incidence of Type 1 Diabetes is increasing rapidly in children. The uptake of insulin pump therapy as a treatment method amongst the paediatric population is also increasing quickly, surpassing the rate of uptake in other groups. Studies have shown varied results regarding the safety of insulin pump therapy in children and adolescents. A study was conducted to determine if delivery accuracy of insulin pumps can potentially affect glycaemic outcomes in younger users. Three insulin pumps were tested: a low-cost prototype pump design, and two commercially available insulin pumps at basal rates of 0.025 U/h, 0.1 U/h and 1 U/h. Bolus accuracy was also tested at a range of bolus sizes between 0.025 U and 1 U. Testing was completed in accordance with IEC60601-2-24, with some modifications made to improve accuracy and ensure results are more generalisable to real-world insulin pump use. Results showed large inaccuracies at smaller dose sizes and potential for insulin pump accuracy errors to cause a clinically relevant shift in blood glucose values, especially at the smaller dose sizes and basal rates used by children and those sensitive to insulin. Further testing is needed with a wider range of commercial insulin pumps to determine if these errors are present in all devices.

Description
Citation
Payne M, Pooke F, Holder-Pearson L, Chase GJ (2023). Insulin pump accuracy at low and minimum delivery rates, in relation to paediatric diabetes care. IFAC-PapersOnLine. 56. 2. 9024-9029.
Keywords
drug delivery systems, insulin pumps, medical devices, diabetes, accuracy analysis
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
32 - Biomedical and clinical sciences::3213 - Paediatrics::321302 - Infant and child health
32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinology
Rights
All rights reserved unless otherwise stated