Lumped Parameter and Feedback Control Models of the Auto-Regulatory Response in the Circle of Willis

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dc.contributor.authorMoorhead, K.T.
dc.contributor.authorDoran, C.V.
dc.contributor.authorChase, Geoff
dc.contributor.authorDavid, T.
dc.date.accessioned2007-07-27T02:41:54Z
dc.date.available2007-07-27T02:41:54Z
dc.date.issued2004en
dc.description.abstractThe Circle of Willis is a ring-like structure of blood vessels found beneath the hypothalamus at the base of the brain. Its main function is to distribute oxygen-rich arterial blood to the cerebral mass. A one-dimensional model of the Circle of Willis has been created to simulate a series of possible clinical scenarios such as occlusions in afferent arteries, absent or string-like circulus vessels, or arterial infarctions. The model captures cerebral haemodynamic auto-regulation by using a Proportional-Integral-Derivative (PID) controller to modify efferent resistances and maintain optimal efferent flowrates for a given circle geometry and afferent blood pressure. Results match limited clinical data and results obtained in prior studies to within 6%. In addition, a set of boundary conditions and geometry is presented for which the auto-regulated system cannot provide the necessary efferent flowrates and perfusion, representing a condition with increased risk of stroke and highlighting the importance of modelling the haemodynamics of the Circle of Willis. The system model created is computationally simple so it can be used to identify at-risk cerebral arterial geometries and conditions prior to surgery or other clinical procedures.en
dc.identifier.citationMoorhead, K.T., Doran, C.V., Chase, J.G. and David,T. (2004) Lumped Parameter and Feedback Control Models of the Auto-Regulatory Response in the Circle of Willis. Computer Methods in Biomechanics and Biomedical Engineering, 7(3), pp. 121-130.en
dc.identifier.issn1025-5842
dc.identifier.urihttp://hdl.handle.net/10092/301
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineering.en
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectCircle of Willisen
dc.subjectCerebral haemodynamicsen
dc.subjectComputational modelen
dc.subjectAuto-regulationen
dc.subjectPID controlleren
dc.subject.marsdenFields of Research::290000 Engineering and Technology::291800 Interdisciplinary Engineering::291801 Fluidisation and fluid mechanicsen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321008 Haematologyen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::320700 Neurosciences::320702 Central nervous systemen
dc.titleLumped Parameter and Feedback Control Models of the Auto-Regulatory Response in the Circle of Willisen
dc.typeJournal Article
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