Physiological sex differences in mechanically ventilated premature neonates: A pilot study

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dc.contributor.authorKim KT
dc.contributor.authorKnopp J
dc.contributor.authorDixon B
dc.contributor.authorChase, Geoff
dc.date.accessioned2021-06-13T23:33:15Z
dc.date.available2021-06-13T23:33:15Z
dc.date.issued2020en
dc.date.updated2021-04-20T06:27:59Z
dc.description.abstractMechanical ventilation (MV) is commonly used in neonatal intensive care units (NICUs) to support breathing. Anecdotally, male infants are harder to ventilate than females. In this study, the pulmonary mechanics of 10 invasively mechanically ventilated neonates from Christchurch Women’s Hospital, recorded during an observational trial with no protocolised change to care, are compared. We hypothesise males have higher specific lung elastance (elastance corrected for weight) than females, due to stiffer and less developed lungs. The specific elastance and resistance is identified for every breath using a single compartment model with a pressure loss term added to compensate for endotracheal tube resistance. Variability is determined by relative percent breath-to-breath variability (%ΔE) in specific elastance. Male infants had higher specific elastance compared to females (P≤0.01) with median [interquartile range] of 1.91[1.33‐2.48] cmH2O.kg/ml and 1.31[0.86‐2.02] cmH2O.kg/mL respectively. Males also had lower %ΔE median IQR of -0.03 [-7.56 - 8.01] and females had 0.59[-12.56 - 12.86]. The results validates our hypothesis that boys have higher elastance than girls. These results also suggests males and females should be ventilated differently.en
dc.identifier.citationKim KT, Knopp J, Dixon B, Chase JG (2020). Physiological sex differences in mechanically ventilated premature neonates: A pilot study. IFAC-PapersOnLine. 53(2). 16173-16178.en
dc.identifier.doihttp://doi.org/10.1016/j.ifacol.2020.12.607
dc.identifier.issn2405-8963
dc.identifier.urihttps://hdl.handle.net/10092/102033
dc.languageen
dc.language.isoen
dc.publisherElsevier BVen
dc.rightsAll rights reserved unless otherwise stateden
dc.rights.urihttp://hdl.handle.net/10092/17651en
dc.subjectphysiological modelen
dc.subjectrespiratory mechanicsen
dc.subjectelastanceen
dc.subjectmodel-baseden
dc.subjectNICUen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3213 - Paediatrics::321303 - Neonatologyen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineeringen
dc.titlePhysiological sex differences in mechanically ventilated premature neonates: A pilot studyen
dc.typeJournal Articleen
uc.collegeFaculty of Engineering
uc.departmentMechanical Engineering
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