Insulin kinetics during hyper-insulinemia euglycemia therapy (HIET)

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dc.contributor.authorPenning, S.
dc.contributor.authorMassion, P.
dc.contributor.authorLe Compte, A.J.
dc.contributor.authorDesaive, T.
dc.contributor.authorChase, Geoff
dc.date.accessioned2013-02-13T23:47:53Z
dc.date.available2013-02-13T23:47:53Z
dc.date.issued2012en
dc.descriptioninvited, 6-pagesen
dc.description.abstractHigh insulin euglycemia therapy (HIET) is a supra-physiological insulin dosing protocol used in acute cardiac failure to reduce dependency on inotropes to augment or generate cardiac output, and is based on the inotropic effects of insulin at high doses up to 45-250x normal daily dose. Such high insulin doses are managed using intravenous glucose infusion to control glycemia and prevent hypoglycemia. However, both insulin dosing and glycemic control in these patients is managed ad-hoc. This research examines a selection of clinical data to determine the effect of high insulin dosing on renal clearance and insulin sensitivity, to assess the feasibility of using model-based methods to control and guide these protocols. The results show that the model and, in particular, the modeled renal clearance constant are adequate and capture measured data well, although not perfectly. Equally, insulin sensitivity over time is similar to broader critical care cohorts in level and variability, and these results are the first time they have been presented for this cohort. While more data is needed to confirm and further specify these results, it is clear that the model used is adequate for controlling HIET in a model-based framework.en
dc.identifier.citationPenning, S., Massion, P., Le Compte, A.J., Desaive, T., Chase, J.G. (2012) Insulin kinetics during hyper-insulinemia euglycemia therapy (HIET). Budapest, Hungary: 8th IFAC Symposium on Biological and Medical Systems (BMS12), 29-31 Aug 2012. Biological and Medical Systems, 8, 1, 295-300.en
dc.identifier.doihttps://doi.org/10.3182/20120829-3-HU-2029.00037
dc.identifier.urihttp://hdl.handle.net/10092/7420
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineeringen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectrenal clearanceen
dc.subjectHIETen
dc.subjectcardiac failureen
dc.subjectcritically illen
dc.subjectmodel-based controlen
dc.subjectinsulin sensitivityen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320102 - Haematologyen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinologyen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320212 - Intensive careen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320214 - Nephrology and urologyen
dc.subject.anzsrcField of Research::09 - Engineering::0903 - Biomedical Engineeringen
dc.titleInsulin kinetics during hyper-insulinemia euglycemia therapy (HIET)en
dc.typeConference Contributions - Published
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