Following the recent earthquakes in Chile (2010) and New Zealand (2010/2011), peculiar failure modes were observed in Reinforced Concrete (RC) walls. These observations have raised a global concern on the contribution of bi-directional loading to these failure mechanisms. One of the failure modes that could potentially result from bidirectional excitations is out-of-plane shear failure. In this paper an overview of the recent experimental and numerical findings regarding out-of-plane shear failure in RC walls are presented. The numerical study presents the Finite Element (FE) simulation of wall D5-6 from the Grand Chancellor Hotel that failed in shear in the out-of-plane direction in the February 2011 Christchurch earthquake. The main objective of the numerical study was to investigate the reasons for this failure mode. The experimental campaign includes the recent experiments conducted in the Structural Engineering Laboratory of the University of Canterbury. The experimental study included three rectangular slender RC walls designed based on NZS3101: 2006-A3 (2017) for three different ductility levels, namely: nominally ductile, limited ductile and ductile. The numerical results showed that high axial load combined with bi-directional loading caused the out-of-plane shear failure in wall D5-6 from the Grand Chancellor Hotel. This was also confirmed and further investigated in the experimental phase of the study.