In this study, we investigate the performance of several parameters as estimators of seismic site effects for sites in northern South America. Investigated parameters include the conventional time-averaged shear wave velocity in the upper 30 m (VS30), the predominant period of the site, and horizontal-to-vertical spectral ratios. To assess the performance of these parameters, we estimate the amplification of seismic waves within shallow soil layers (i.e., site effects) at recording stations across northern South America. The site amplification is estimated by analyzing the residuals calculated from ground-motion records with respect to model predictions for hard-rock site conditions. Several functional forms were introduced to express the linear site amplification in terms of the explored parameters. We evaluate the efficacy of the parameters, as well as their advantages and limitations, by considering their impact in the site-to-site standard deviation of the residuals between observations and predictions using the introduced functional forms.