Predicting the Effects of Changing PEEP Using a Basis Function Method

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dc.contributor.authorArgus FJ
dc.contributor.authorSutherland CJ
dc.contributor.authorChakson J
dc.contributor.authorMcNearney E
dc.contributor.authorDickson JL
dc.contributor.authorRedmond D
dc.contributor.authorKim K
dc.contributor.authorDocherty PD
dc.contributor.authorChase, Geoff
dc.date.accessioned2018-01-11T22:59:38Z
dc.date.available2018-01-11T22:59:38Z
dc.date.issued2017en
dc.date.updated2017-08-07T04:06:54Z
dc.description.abstractCurrent methods to optimise mechanical ventilation involve increasing positive end expiratory pressure (PEEP) in steps to maximize recruitment. If PEEP is too high, overdistension and damage occur. There is thus an inherent risk involved when increasing PEEP. This study predicts dynamic elastance and lung mechanics for higher PEEP using clinically relevant elastance basis functions, capturing distension, recruitment and constant stiffness, in a first order model of lung mechanics. The clinically relevant basis functions were used to fit elastance using a single compartment lung model for 10 patients undergoing recruitment maneuvers, where 2-4 PEEP levels were analysed, and then used to predict the elastance and pressure waveforms for PEEP level increases of 5 and 10 cmH2O. The mean error for the pressure fits from the clinically relevant basis functions was 2.06%. Mean error for pressure predictions with a PEEP level increase of 5 cmH2O was 3.8-5.5%. Mean error for PEEP level increases of 10 cmH2O was slightly higher, between 5.0 and 6.6%. Good pressure fits and predictions show these basis functions accurately fit and predict elastance and thus lung behavior at increased PEEP levels. Each clinically relevant basis function behaved as expected, however improvements to the identifiability of distension would further improve the overall accuracy.en
dc.identifier.citationArgus FJ, Sutherland CJ, Chakson J, McNearney E, Dickson JL, Redmond D, Kim K, Docherty PD, Chase JG (2017). Predicting the Effects of Changing PEEP Using a Basis Function Method. Toulouse, France: IFAC 20th WC 2017. 09/07/2017-14/07/2017. IFAC-PapersOnLine.en
dc.identifier.doihttps://doi.org/10.1016/j.ifacol.2017.08.1084
dc.identifier.urihttp://hdl.handle.net/10092/14943
dc.language.isoen
dc.rightsCreative Commons Attribution Non-Commercial No Derivatives Licenseen
dc.subjectpressureen
dc.subjectpredictionen
dc.subjectelastanceen
dc.subjectlungen
dc.subjectrecruitmenten
dc.subjectairwayen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineeringen
dc.subject.anzsrcFields of Research::32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320103 - Respiratory diseasesen
dc.titlePredicting the Effects of Changing PEEP Using a Basis Function Methoden
dc.typeConference Contributions - Publisheden
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