Adaptive bolus-based set-point regulation of hyperglycemia in critical care

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dc.contributor.authorLin, J.
dc.contributor.authorChase, Geoff
dc.contributor.authorShaw, Geoff
dc.contributor.authorDoran, C.V.
dc.contributor.authorHann, C.E.
dc.contributor.authorRobertson, M.B.
dc.contributor.authorBrowne, P.M.
dc.contributor.authorLotz, T.
dc.contributor.authorWake, G.C.
dc.contributor.authorBroughton, B.
dc.date.accessioned2007-07-05T03:41:00Z
dc.date.available2007-07-05T03:41:00Z
dc.date.issued2004en
dc.description.abstractCritically ill patients are often hyperglycemic and extremely diverse in their dynamics. Consequently, fixed protocols and sliding scales can result in error and poor control. A two-compartment glucose-insulin system model that accounts for time-varying insulin sensitivity and endogenous glucose removal, along with two different saturation kinetics is developed and verified in proof-of-concept clinical trials for adaptive control of hyperglycemia. The adaptive control algorithm monitors the physiological status of a critically ill patient, allowing real-time tight glycemic regulation. The bolus-based insulin administration approach is shown to result in safe, targeted stepwise glycemic reduction for three critically ill patients.en
dc.identifier.citationLin, J., Chase, J.G., Shaw, G.M., Doran, C.V., Hann, C.E., Robertson, M.B., Browne, P.M., Lotz, T., Wake, G.C., Broughton, B. (2004) Adaptive bolus-based set-point regulation of hyperglycemia in critical care. San Francisco, CA, USA: 26th Annual International Conference of the Engineering in Medicine and Biology Society, 1-5 Sep 2004. EMBC 2004 Conference Proceedings, 2, 3463-3466.en
dc.identifier.isbn978-0-7803-8440-8
dc.identifier.urihttp://hdl.handle.net/10092/153
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineering.en
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectadaptive controlen
dc.subjectcritical careen
dc.subjectglucose-insulin system modelen
dc.subjecthyperglycemiaen
dc.subjectinsulin bolusen
dc.subject.marsdenFields of Research::230000 Mathematical Sciences::230100 Mathematics::230119 Systems theory and controlen
dc.subject.marsdenFields of Research::290000 Engineering and Technology::290500 Mechanical and Industrial Engineering::290501 Mechanical engineeringen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321008 Haematologyen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::320600 Medical Physiology::320603 Systems physiologyen
dc.titleAdaptive bolus-based set-point regulation of hyperglycemia in critical careen
dc.typeConference Contributions - Published
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