Quantifying neonatal pulmonary mechanics in mechanical ventilation

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dc.contributor.authorKim KT
dc.contributor.authorKnopp J
dc.contributor.authorDixon B
dc.contributor.authorChase, Geoff
dc.date.accessioned2019-08-23T02:18:13Z
dc.date.available2019-08-23T02:18:13Z
dc.date.issued2019en
dc.date.updated2019-07-03T04:22:31Z
dc.description.abstract© 2019 Elsevier Ltd Background: Mechanical Ventilation (MV) is an important intensive care therapy. It is often used in neonatal intensive care units (NICUs) to treat respiratory distress syndrome. This paper uses model-based methods in a first in-depth attempt to quantify the underlying lung mechanics in NICU patients. Methods: Up to 24 h of airway flow and pressure data were recorded in 10 mechanically ventilated patients. A single compartment model with added term for the pressure drop across the endotracheal tube is used to identify breath-specific elastance and resistance. Result: The model was fitted to 422,475 (79%) breaths of 535,428, with the remainder comprising a range of asynchronies. Elastance was median 1.62 [IQR: 0.85–2.25] cmH 2 O/ml and resistance 5.22 [0.00–33.85] cmH 2 O.s/ml. Patients treated with surfactant therapy had significantly lower specific elastance (adjusting for weight) than those without (p ≤ 0.01). A decrease in elastance with increasing weight was also noted. Conclusion: The single compartment model was successfully fit with low error. The subgroup cohorts showed expected trends and further validates the identified model values. There was significant breath-to-breath variability in elastance within and between patients.en
dc.identifier.citationKim KT, Knopp J, Dixon B, Chase G (2019). Quantifying neonatal pulmonary mechanics in mechanical ventilation. Biomedical Signal Processing and Control. 52. 206-217.en
dc.identifier.doihttps://doi.org/10.1016/j.bspc.2019.04.015
dc.identifier.issn1746-8094
dc.identifier.issn1746-8108
dc.identifier.urihttp://hdl.handle.net/10092/16974
dc.languageEnglish
dc.language.isoen
dc.publisherElsevier BVen
dc.rightsCreative Commons Attribution Non-Commercial No Derivatives Licenseen
dc.subjectNeonatal Intensive Care Unit (NICU)en
dc.subjectelastanceen
dc.subjectpulmonary mechanicsen
dc.subjectneonatalen
dc.subjectrespiratoryen
dc.subject.anzsrcFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineeringen
dc.titleQuantifying neonatal pulmonary mechanics in mechanical ventilationen
dc.typeJournal Articleen
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