A Subcutaneous Insulin Pharmacokinetic Model for Computer Simulation in a Diabetes Decision Support Role: Validation and Simulation

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dc.contributor.authorChase, Geoff
dc.contributor.authorHann, C.E.
dc.contributor.authorShaw, Geoff
dc.contributor.authorLotz, T.F.
dc.contributor.authorLin, J.
dc.contributor.authorLe Compte, A.J.
dc.contributor.authorWong, J.
dc.date.accessioned2009-07-22T21:04:21Z
dc.date.available2009-07-22T21:04:21Z
dc.date.issued2008en
dc.descriptionCompanion paper #2en
dc.description.abstractObjective: The goal of this study was to validate a previously derived and identified physiological subcutaneous (SC) insulin absorption model for computer simulation in a clinical diabetes decision support role using published pharmacokinetic summary measures. Methods: Validation was performed using maximal plasma insulin concentration (Cmax) and time to maximal concentration (tmax) pharmacokinetic summary measures. Values were either reported or estimated from 37 pharmacokinetic studies over six modeled insulin types. A validation comparison was made to equivalent pharmacokinetic summary measures calculated from model generated curves fitted to respective plasma insulin concentration data. The validation result was a measure of goodness of fit. Validation for each reported study was classified into one of four cases. Results: Of 37 model fits, 22 were validated on both the Cmax and the tmax summary measures. Another 6 model fits were partially validated on one measure only due to lack of reporting on the second measure with errors to reported or estimated ranges of <12%. Another 7 studies could not be validated on either measure because of inadequate reported clinical data. Finally, 2 separate model fits to data from the same study failed the validation with 90 and 71% error on tmax only, which was likely caused by protocol-based error. No model fit failed the validation on both measures.en
dc.identifier.citationWong, J., Chase, J.G., Hann, C.E., Shaw, G.M., Lotz, T.F., Lin, J., Le Compte, A.J. (2008) A Subcutaneous Insulin Pharmacokinetic Model for Computer Simulation in a Diabetes Decision Support Role: Validation and Simulation. Journal of Diabetes Science and Technology, 2(4), pp. 672-680.en
dc.identifier.issn1932-2968
dc.identifier.urihttp://hdl.handle.net/10092/2613
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineering.en
dc.relation.urihttp://www.journalofdst.org/Journal/pdf/July2008/VOL-2-4-ORG13-WONG2.pdfen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectdiabetesen
dc.subjectcompartmental modelsen
dc.subjecthyperglycemiaen
dc.subjectinsulinen
dc.subjectblood glucoseen
dc.subjectsimulationen
dc.subjectsubcutaneous injectionen
dc.subjectdecision supporten
dc.subject.marsdenFields of Research::290000 Engineering and Technology::291500 Biomedical Engineering::291504 Biomechanical engineeringen
dc.subject.marsdenFields of Research::290000 Engineering and Technology::290500 Mechanical and Industrial Engineering::290501 Mechanical engineeringen
dc.titleA Subcutaneous Insulin Pharmacokinetic Model for Computer Simulation in a Diabetes Decision Support Role: Validation and Simulationen
dc.typeJournal Article
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