Background This study examines the performance of site response analysis via nonlinear total-stress 1D wave-propagation for modelling site effects in physics-based ground motion simulations of the 2010-2011 Canterbury, New Zealand earthquake sequence. This approach allows for explicit modeling of 3D ground motion phenomena at the regional scale, as well as detailed nonlinear site effects at the local scale. The approach is compared to a more commonly used empirical VS30 (30 m time-averaged shear wave velocity)-based method for computing site amplification as proposed by Graves and Pitarka (2010, 2015), and to empirical ground motion prediction via a ground motion model (GMM).