An as-built reinforced concrete (RC) frame building designed and constructed according to pre-1970s code design construction practice has been recently tested on the shake table at the University of Canterbury. The specimen, 1/2.5 scaled version of the original prototype, consists of two 3-storey 2-bay asymmetric frames in parallel, one interior and one exterior, jointed together by transverse beams and floor slabs. Following the benchmark test, a retrofit intervention has been proposed to rehabilitate the tested specimen. In this paper, detailed information on the assessment and design of the seismic retrofit procedure using GFRP (glass fibre reinforced polymer) materials is given for the whole frame. Hierarchy of strength and sequence of events (damage mechanisms) in the panel zone region are evaluated using a moment-axial load (M-N) interaction performance domain, according to a performance-based retrofit philosophy. Specific limit states or design objectives are targeted with attention given to both strength and deformation limits. In addition, an innovative retrofit solution using FRP anchor dowels for the corner beam-column joints with slabs is proposed. Finally, in order to provide a practical tool for engineering practice, the retrofit procedure is provided in a step-by step flowchart fashion.