EFBAT: exact family-based association tests

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dc.contributor.authorSchneiter, K.
dc.contributor.authorDegnan, J.H.
dc.contributor.authorCorcoran, C.
dc.contributor.authorXu, X.
dc.contributor.authorLaird, N.
dc.date.accessioned2010-05-25T00:04:59Z
dc.date.available2010-05-25T00:04:59Z
dc.date.issued2007en
dc.description.abstractBackground: Family-based association tests are important tools for investigating genetic risk factors of complex diseases. These tests are especially valuable for being robust to population structure. We introduce a tool, EFBAT, which performs exact family-based tests of association for X-chromosome and autosomal biallelic markers. Results: The program EFBAT extends a network algorithm previously applied to autosomal markers to include the X-chromosome and to perform tests of association under the null hypotheses "no association, no linkage" and "no association in the presence of linkage" under additive, dominant and recessive genetic models. These tests are valid regardless of patterns of missing familial data. Conclusion: The general framework for performing exact family-based association tests has been usefully extended to the X-chromosome, particularly for the hypothesis of "no association in the presence of linkage" and for different genetic models.en
dc.identifier.citationSchneiter, K., Degnan, J.H., Corcoran, C., Xu, X., Laird, N. (2007) EFBAT: exact family-based association tests. BMC Genetics, 8, pp. 86.en
dc.identifier.doihttps://doi.org/10.1186/1471-2156-8-86
dc.identifier.issn1471-2156
dc.identifier.urihttp://hdl.handle.net/10092/3880
dc.language.isoen
dc.publisherUniversity of Canterbury. Mathematics and Statisticsen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subject.marsdenFields of Research::270000 Biological Sciencesen
dc.subject.marsdenFields of Research::270000 Biological Sciences::270200 Geneticsen
dc.titleEFBAT: exact family-based association testsen
dc.typeJournal Article
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