Adaptive bolus-based targeted glucose regulation of hyperglycaemia in critical care

Simple item page
dc.contributor.authorChase, Geoff
dc.contributor.authorShaw, Geoff
dc.contributor.authorLin, J.
dc.contributor.authorDoran, C.V.
dc.contributor.authorHann, C.E.
dc.contributor.authorRobertson, M.B.
dc.contributor.authorBrowne, P.M.
dc.contributor.authorLotz, T.
dc.contributor.authorWake, G.C.
dc.contributor.authorBroughton, R.
dc.date.accessioned2007-07-24T05:11:20Z
dc.date.available2007-07-24T05:11:20Z
dc.date.issued2005en
dc.description.abstractCritically ill patients are often hyperglycemic and extremely diverse in their dynamics. Consequently, fixed protocols and sliding scales can result in error and poor control. A two-compartment glucose-insulin system model that accounts for time-varying insulin sensitivity and endogenous glucose removal, along with two different saturation kinetics is developed and verified in proof-of-concept clinical trials for adaptive control of hyperglycemia. The adaptive control algorithm monitors the physiological status of a critically ill patient, allowing real-time tight glycemic regulation. The bolus-based insulin administration approach is shown to result in safe, targeted stepwise glycemic reduction for three critically ill patients.en
dc.identifier.citationChase, J.G., Shaw, G.M., Lin, J., Doran, C.V., Hann, C.E., Robertson, M.B., Browne, P.M., Lotz, T., Wake, G.C., Broughton, R. (2005) Adaptive bolus-based targeted glucose regulation of hyperglycaemia in critical care. Medical Engineering and Physics, 27(1), pp. 1-11.en
dc.identifier.issn1350-4533
dc.identifier.urihttp://hdl.handle.net/10092/271
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineering.en
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectadaptive controlen
dc.subjectcritical careen
dc.subjectglucose-insulin system modelen
dc.subjecthyperglycemiaen
dc.subjectinsulin bolusen
dc.subject.marsdenFields of Research::290000 Engineering and Technology::291500 Biomedical Engineeringen
dc.titleAdaptive bolus-based targeted glucose regulation of hyperglycaemia in critical careen
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12593047_Main.pdf
Size:
75.74 KB
Format:
Adobe Portable Document Format
Download
Collections
Engineering: Journal Articles