Blood Glucose Control in Neonatal Intensive Care with Model-Based Controllers

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dc.contributor.authorLeCompte, A.J.
dc.contributor.authorChase, Geoff
dc.contributor.authorLynn, A.
dc.contributor.authorHann, C.E.
dc.contributor.authorShaw, Geoff
dc.contributor.authorLin, J.
dc.date.accessioned2010-04-12T22:31:51Z
dc.date.available2010-04-12T22:31:51Z
dc.date.issued2009en
dc.descriptioninviteden
dc.description.abstractPremature neonates often experience hyperglycaemia, which has been linked to increased mortality and worsened outcomes. Insulin therapy can assist in controlling blood glucose levels. However a reliable, robust control protocol is required to avoid hypoglycaemia and to meet nutrition goals. This study presents an adaptive, model-based predictive controller designed to incorporate the unique metabolic state and control parameters of the neonate. Controller performance was tested in virtual trials on a 25 patient retrospective cohort and 24-hour pilot clinical trials. The effects of measurement frequency and BG sensor error were also evaluated. Time in the 4 – 7 mmol/L BG band was increased by 110%-145% compared to retrospective control for that cohort, with fewer hypoglycaemic measurements. Controllers were robust to BG sensor errors.en
dc.identifier.citationLeCompte, A.J., Chase, J.G., Lynn, A., Hann, C.E., Shaw, G.M., Lin, J. (2009) Blood Glucose Control in Neonatal Intensive Care with Model-Based Controllers. Aalborg, Denmark: 7th IFAC Symposium on Modeling and Control in Biomedical Systems (MCBMS09), 12-14 Aug 2009. 7, 1.en
dc.identifier.doihttps://doi.org/10.3182/20090812-3-DK-2006.0031
dc.identifier.isbn978-3-902661-49-4
dc.identifier.urihttp://hdl.handle.net/10092/3706
dc.language.isoen
dc.publisherUniversity of Canterbury. Mechanical Engineeringen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectinsulin sensitivityen
dc.subjectcontrol algorithmsen
dc.subjectphysiological modelsen
dc.subjectsimulationen
dc.subjectintensive careen
dc.subject.marsdenFields of Research::290000 Engineering and Technology::291500 Biomedical Engineering::291504 Biomechanical engineeringen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321009 Intensive careen
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321004 Endocrinologyen
dc.subject.marsdenFields of Research::230000 Mathematical Sciences::230100 Mathematicsen
dc.titleBlood Glucose Control in Neonatal Intensive Care with Model-Based Controllersen
dc.typeConference Contributions - Published
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