Studies on marine natural products
| dc.contributor.author | Hart, Joanne B. | en |
| dc.date.accessioned | 2013-06-17T00:41:14Z | |
| dc.date.available | 2013-06-17T00:41:14Z | |
| dc.date.issued | 1995 | en |
| dc.description.abstract | The halichondrins are a series of polyether macrolides displaying potent in vitro and in vivo antitumour activities and, as such, represent important leads as anticancer drugs. These compounds had previously been isolated from a number of unrelated marine sponges, such as Lissodendoryx sp., a high yielding deep-water sponge located off the Kaikoura coast of New Zealand. Structure-activity relationships in the halichondrin senes have now been investigated. Hemi-synthetic modifications of selected naturally-occurring halichondrins have produced over fourteen new analogues. The biological activities of twelve of these analogues have been assessed in an in-house P388 in vitro assay and in the National Cancer Institute's (USA) in vitro sixty cell-line human tumour panel. An analysis of these data has shown that the lactone ring (C1-C30), the olefinic functionalities (C19 and C26), the natural C38 stereochemistry and the tricyclo ring system (C-E rings) are essential structural features of the halichondrins. The characterisation of the hemi-synthetic derivatives has been facilitated by the full NMR spectroscopic assignments of halichondrin B and homohalichondrin B. The future progress of the halichondrins as anticancer drugs will have been assisted by the development of an understanding of the general chemistry of the halichondrins. | en |
| dc.identifier.uri | http://hdl.handle.net/10092/7850 | |
| dc.identifier.uri | http://dx.doi.org/10.26021/5856 | |
| dc.language.iso | en | |
| dc.publisher | University of Canterbury. Chemistry | en |
| dc.relation.isreferencedby | NZCU | en |
| dc.rights | Copyright Joanne B. Hart | en |
| dc.rights.uri | https://canterbury.libguides.com/rights/theses | en |
| dc.title | Studies on marine natural products | en |
| dc.type | Theses / Dissertations | |
| thesis.degree.discipline | Chemistry | en |
| thesis.degree.grantor | University of Canterbury | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |
| uc.bibnumber | 514653 | en |
| uc.college | Faculty of Science | en |
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