Automated Vision-Based Force Measurement of Moving C. elegans

Type of content
Conference Contributions - Published
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Publisher
University of Canterbury. Chemical and Process Engineering
University of Canterbury. Electrical and Computer Engineering
University of Canterbury. Mechanical Engineering
Journal Title
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Date
2010
Authors
Ghanbari, A.
Nock, V.
Blaikie, R.J.
Chen, X.
Chase, Geoff
Wang, W.
Abstract

Abstract—this paper reports an automated tracking and force measurement system for C. elegans in motion, based on microscopy computer vision. A polydimethylsiloxane (PDMS) device was microfabricated to allow C. elegans to move in a matrix of micropillars in a channel. An image processing algorithm has been developed to track the worm and deflecting micropillars automatically in purpose of quantifying multipoint locomotive forces of a moving C. elegans. The developed system is able to visually resolve force with a 0.33 µN resolution. A maximum force level of 55.41 µN for a young adult wild type C. elegans was observed.

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Citation
Ghanbari, A., Nock, V., Blaikie, R.J., Chen, X., Chase, J.G., Wang, W. (2010) Automated Vision-Based Force Measurement of Moving C. elegans. Toronto, Canada: 6th Annual IEEE Conference on Automation Science and Engineering (CASE 2010), 21-24 Aug 2010. 198-203.
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ANZSRC fields of research
Field of Research::09 - Engineering::0913 - Mechanical Engineering
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