An analytical method and a genetic algorithm searching method are used to estimate the kinetic properties of wood based on the assumptions of two different multiple-component schemes. The pyrolysis model in Fire Dynamics Simulator is used to model material-scale and bench-scale experiments using the kinetic properties derived from the two methods. It is found that the use of the kinetic properties from the different methods and the different component assumptions cause slight differences in the prediction of pyrolysis behaviour for the material-scale experiments, however, no significant differences are found in the prediction of heat release rate for bench-scale experiments.