Higher Insulin Resistance in Female ICU patients (2020)
Introduction: Sex differences in the metabolic response to critical illness are unknown. This retrospective analysis examines potential differences in the evolution of insulin sensitivity (SI) and its variability (%ΔSI) between sexes. Significant differences would suggest differences in the metabolic stress response and glycemic response to insulin therapy, and, thus, the need for more personalized glycemic control (GC). Methods: Retrospective data from 145 ICU patients (N=8710 hours) are used to hourly identify hourly model-based SI and its rate of change %ΔSI in 6-hour blocks from ICU admission to 72 hours. The evolution of SI and %ΔSI are compared for males and females. Hypothesis testing (95% confidence interval (CI) bootstrapped difference in medians) assesses if differences are significant, and equivalence testing assesses if differences are clinically equivalent. Results: Females have significantly lower SI levels than males (p<0.05), and this difference is not clinically equivalent (Figure 1; top). Differences in %ΔSI are not significant (p>0.05), and these differences are clinically equivalent (Figure 1; bottom).
CitationUyttendaele V, Knopp JL, Gottlieb R, Shaw GM, Desaive T, Chase G (2020). Higher Insulin Resistance in Female ICU patients. Brussels, Belgium: e-ISICEM: International Symposium on Intensive Care and Emergency Medicine (virtual). 15/09/2020-18/09/2020. Critical Care (UK). 24. Suppl 2. 14-14.
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ANZSRC Fields of Research40 - Engineering::4003 - Biomedical engineering::400306 - Computational physiology
32 - Biomedical and clinical sciences::3202 - Clinical sciences::320212 - Intensive care
32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinology
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Uyttendaele V; Gottlieb R; Shaw, Geoff; Desaive T; Knopp, Jennifer; Chase, Geoff (Elsevier BV, 2020)Glycaemic control (GC) has been associated with improved outcomes in critically ill patients. However, inter- and intra- patient metabolic variability significantly increase the risk of hypoglycaemia when using insulin ...
Uyttendaele, Vincent; Knopp, Jennifer; Shaw, Geoff; Desaive T; Chase, Geoff (BMC, 2020)
Pirotte M; Morimont P; Lambermont B; Shaw, Geoff; Desaive T; Uyttendaele, Vincent; Knopp, Jennifer; Chase, Geoff (BMC, 2020)Introduction: Stress-induced hyperglycemia is a common complication associated with higher morbidity and mortality in ICU patients. The Stochastic TARgeted (STAR) glycemic control (GC) framework provides consistent, ...