Now showing items 1-3 of 3
Studies on the inhibitor selectivity and inhibitory signal transfer of a-Isopropylmalate synthase
(University of Canterbury. Chemistry, 2013)
α-Isopropylmalate synthase (α-IPMS) is responsible for catalysing the first committed step in leucine biosynthesis. This pathway is found in plants and microorganisms, including pathogenic bacteria such as Mycobacterium ...
Studies into the allosteric regulation of α-isopropylmalate synthase
(University of Canterbury. Chemistry Department, 2012)
α-Isopropylmalate synthase (α-IPMS) catalyses the first committed step in leucine biosynthesis in bacteria, including Neisseria meningitidis and Mycobacterium tuberculosis. It catalyses the condensation of α-ketoisovalerate ...
Investigating the selectivity and mechanism of allosteric regulation in α-IPMS enzymes
(University of Canterbury. Department of Chemistry, 2015)
Enzymes are nature’s wizards: balanced delicately on the margin of order and entropy, they perform chemical reactions and syntheses at rates and yields human chemists can only dream of. Many possess exquisite control ...