Anxiolysis and recognition memory enhancement with long-term supplemental ascorbic acid (vitamin C) in normal rats: possible dose dependency and sex differences

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dc.contributor.authorHughes, R.N.
dc.contributor.authorHancock, N.J.
dc.contributor.authorThompson, R.M.
dc.date.accessioned2015-07-27T23:49:24Z
dc.date.available2015-07-27T23:49:24Z
dc.date.issued2015en
dc.description.abstractTo investigate a possible dose-response relationship and sex differences for anxiolytic and memory-enhancing effects of ascorbic acid (vitamin C), an adult PVG /c hooded rats were individually treated for 8 weeks with approximately 61, 114 or 160 mg/kg/ day of ascorbic acid in their drinking water. After their treatment, over 3 consecutive days they experienced a 5-min trial in an open field (OF) followed by a 5-min trial in an elevated plus maze (EPM), and then finally a 5-min novel object recognition (NOR) test in the OF. Dose-related anxiolytic effects were observed that to some extent depended on the measure of anxiety. In other words, anxiolytic effects were evident in higher frequencies of walking with 114 mg/kg and 61 mg/kg, higher frequencies of rearing and lower frequencies of grooming in the OF as well as more frequent occupation of the EPM open arms. Rats treated with 160 mg/kg explored a novel versus familiar object in the NOR test to a significantly greater extent than control rats thereby suggesting enhancement of their recognition memory. Overall, it appeared that the anxiolytic effects of ascorbic acid were more typical of the lowest dose, whereas memory enhancement appeared to be confined to the highest dose. While there were a number of significant sex differences, there was no evidence of differences between females and males in the effects of ascorbic acid.en
dc.identifier.citationHughes, R.N., Hancock N.J., Thompson R.M. (2015) Anxiolysis and recognition memory enhancement with long-term supplemental ascorbic acid (vitamin C) in normal rats: possible dose dependency and sex differences. Annals of Neuroscience and Psychology, 2, pp. 2.en
dc.identifier.urihttp://hdl.handle.net/10092/10708
dc.language.isoen
dc.publisherUniversity of Canterbury. Psychologyen
dc.relation.urihttp://www.vipoa.org/journals/pdf/244441130.pdfen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subjectAscorbic aciden
dc.subjectanxiolysisen
dc.subjectratsen
dc.subjectopen fielden
dc.subjectelevated plus mazeen
dc.subjectnovel object recognitionen
dc.subject.anzsrcField of Research::17 - Psychology and Cognitive Sciences::1701 - Psychology::170101 - Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)en
dc.titleAnxiolysis and recognition memory enhancement with long-term supplemental ascorbic acid (vitamin C) in normal rats: possible dose dependency and sex differencesen
dc.typeJournal Article
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