Comparison of model based and clinical blood glucose evolution during and after anhepatic status

Type of content
Conference Contributions - Other
Publisher's DOI/URI
Thesis discipline
Degree name
Publisher
University of Canterbury. Mechanical Engineering
Journal Title
Journal ISSN
Volume Title
Language
Date
2013
Authors
Homlok, J.
Chase, Geoff
Turi, Cs
Benyo, B.
Abstract

Blood glucose (BG) control is a major difficulty during liver transplantation (LT). A model-based approach to analysis and control can enhance the efficiency of BG management during LT surgery. An existing clinically validated metabolic model was fitted to data from 8 LT patients. The reperfusion part of the post-anhepatic phase of LT shows a clear consistent dynamic rise in blood glucose (BG) level that would enable better prediction of future BG in this phase. Model fitting errors showed that the fundamental model captured all primary dynamics but parameter adjustment to reflect known conditions during LT surgery in specific phases would improve model quality.

Description
Citation
Homlok, J., Chase, J.G., Turi, Cs., Benyo, B. (2013) Comparison of model based and clinical blood glucose evolution during and after anhepatic status. Graz, Austria: Biomedizinische Technik Conference (BMT 2013), 19-21 Sep 2013. 2pp.
Keywords
liver transplant, blood glucose, reperfusion, metabolic model
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Fields of Research::32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320102 - Haematology
Fields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320226 - Surgery
Fields of Research::32 - Biomedical and clinical sciences::3205 - Medical biochemistry and metabolomics::320507 - Metabolic medicine
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