Ritz, C.Baty, F.Streibig, J.C.Gerhard, D.2016-01-252016-01-252015Ritz, C., Baty, F., Streibig, J.C., Gerhard, D. (2015) Dose-Response Analysis Using R. PloS one, 10(12), pp. e0146021.http://hdl.handle.net/10092/11700Dose-response analysis can be carried out using multi-purpose commercial statistical software, but except for a few special cases the analysis easily becomes cumbersome as relevant, non-standard output requires manual programming. The extension package drc for the statistical environment R provides a flexible and versatile infrastructure for dose-response analyses in general. The present version of the package, reflecting extensions and modifications over the last decade, provides a user-friendly interface to specify the model assumptions about the dose-response relationship and comes with a number of extractors for summarizing fitted models and carrying out inference on derived parameters. The aim of the present paper is to provide an overview of state-of-the-art dose-response analysis, both in terms of general concepts that have evolved and matured over the years and by means of concrete examples.enJournal ArticleField of Research::01 - Mathematical Sciences::0104 - Statistics::010401 - Applied StatisticsFields of Research::46 - Information and computing sciences::4612 - Software engineering::461204 - Programming languageshttps://doi.org/10.1371/journal.pone.0146021